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Gene Review:

OCLM - oculomedin

Homo sapiens

Synonyms: Oculomedin, TISR, Trabecular meshwork-inducible stretch response protein

Fujiwara, N. et al., Tepper, R. et al., Leung, Y.F. et al., Eriksen, B. et al.

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Disease relevance of OCLM

CONCLUSIONS: Oculomedin may play a role in the function of the trabecular meshwork and also in the development of primary open-angle glaucoma [1].
RESULTS: Sonographically, more complex structures and echogenic lesions were found in the OCLMP and malignant tumors than in the cystadenomas, and the difference was statistically significant [2].
Color blood flow imaging revealed a similar resistant index (RI) in the OCLMP (0.487 +/- 0.07) and cystadenomas (0.489 +/- 0.09) when compared with statistically significant lower RI in the ovarian carcinomas (0.391 +/- 0.05) (P < 0.001) [2].

High impact information on OCLM

We investigated the coding exon and promoter sequence in the trabecular meshwork-inducible stretch response (TISR)/oculomedin gene for mutations in Chinese primary open angle glaucoma (POAG) subjects [3].
Immunohistochemically, oculomedin protein was localized to the trabecular meshwork, Schlemm's canal endothelium, retinal photoreceptor cells, and corneal and conjunctival epithelium [1].

Chemical compound and disease context of OCLM

Paraffin-embedded archival specimens from 45 cases of ovarian carcinoma of low malignant potential (OCLMP) were analyzed by flow cytometry (FCM) using propidium iodide (PI) staining [4].

Analytical, diagnostic and therapeutic context of OCLM

RESULTS: Western blot analysis showed that oculomedin protein was expressed only in stretched trabecular cells, not in control trabecular cells in culture [1].

References

Protein expression, genomic structure, and polymorphisms of oculomedin. Fujiwara, N., Matsuo, T., Ohtsuki, H. Ophthalmic Genet. (2003) [Pubmed]
Sonographic and Doppler flow characteristics of ovarian tumors of low-malignant potential. Tepper, R., Altaras, M., Zalel, Y., Goldberger, S., Cohen, I., Beyth, Y., Ben-Baruch, G. Journal of clinical ultrasound : JCU. (1997) [Pubmed]
Absence of trabecular meshwork-inducible stretch response (TISR)/oculomedin gene and proximal promoter mutation in primary open angle glaucoma patients. Leung, Y.F., Baum, L., Lam, D.S., Fan, D.S., Chua, J.K., Pang, C.P. Hum. Genet. (2000) [Pubmed]
Dual-parameter flow cytometric analysis coupling the measurements of forward-angle light scatter and DNA content of archival ovarian carcinomas of low malignant potential. Eriksen, B., Miller, D.S., Murad, T.M., Lurain, J.R., Bauer, K.D. Anal. Quant. Cytol. Histol. (1991) [Pubmed]

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