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Gene Review

OCLM  -  oculomedin

Homo sapiens

Synonyms: Oculomedin, TISR, Trabecular meshwork-inducible stretch response protein
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Disease relevance of OCLM

  • CONCLUSIONS: Oculomedin may play a role in the function of the trabecular meshwork and also in the development of primary open-angle glaucoma [1].
  • RESULTS: Sonographically, more complex structures and echogenic lesions were found in the OCLMP and malignant tumors than in the cystadenomas, and the difference was statistically significant [2].
  • Color blood flow imaging revealed a similar resistant index (RI) in the OCLMP (0.487 +/- 0.07) and cystadenomas (0.489 +/- 0.09) when compared with statistically significant lower RI in the ovarian carcinomas (0.391 +/- 0.05) (P < 0.001) [2].

High impact information on OCLM


Chemical compound and disease context of OCLM


Analytical, diagnostic and therapeutic context of OCLM

  • RESULTS: Western blot analysis showed that oculomedin protein was expressed only in stretched trabecular cells, not in control trabecular cells in culture [1].


  1. Protein expression, genomic structure, and polymorphisms of oculomedin. Fujiwara, N., Matsuo, T., Ohtsuki, H. Ophthalmic Genet. (2003) [Pubmed]
  2. Sonographic and Doppler flow characteristics of ovarian tumors of low-malignant potential. Tepper, R., Altaras, M., Zalel, Y., Goldberger, S., Cohen, I., Beyth, Y., Ben-Baruch, G. Journal of clinical ultrasound : JCU. (1997) [Pubmed]
  3. Absence of trabecular meshwork-inducible stretch response (TISR)/oculomedin gene and proximal promoter mutation in primary open angle glaucoma patients. Leung, Y.F., Baum, L., Lam, D.S., Fan, D.S., Chua, J.K., Pang, C.P. Hum. Genet. (2000) [Pubmed]
  4. Dual-parameter flow cytometric analysis coupling the measurements of forward-angle light scatter and DNA content of archival ovarian carcinomas of low malignant potential. Eriksen, B., Miller, D.S., Murad, T.M., Lurain, J.R., Bauer, K.D. Anal. Quant. Cytol. Histol. (1991) [Pubmed]
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