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Gene Review

Hoxc11  -  homeobox C11

Mus musculus

Synonyms: Homeobox protein Hox-3.7, Homeobox protein Hox-C11, Hox-3.7, Hoxc-11
 
 
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High impact information on Hoxc11

  • As described in this study, removal of the last Hox11 paralogous member, Hoxc11, results in the complete loss of metanephric kidney induction [1].
  • Loss of fibula in mice overexpressing Hoxc11 [2].
  • This interpretation is further corroborated by Hoxc11 reporter gene expression in the joint areas at embryonic day 15.5, suggesting an involvement of the periarticular perichondrium in generating the mutant phenotype [2].
  • Hoxc11 mRNA is found in the most posterior region of the developing embryo commencing at 9.5 days of gestation [3].
  • The Hoxc11 gene encodes a 304 amino acid protein which is translated from a 2.2 kb transcript, derived from two exons [3].
 

Anatomical context of Hoxc11

 

Other interactions of Hoxc11

  • As a prerequisite for studying the role of the AbdB-related Hoxc genes during limb development, we have isolated and mapped the three predicted AbdB-related Hoxc-11, -12, and -13 loci, thus defining the 5' end of the Hoxc cluster [4].

References

  1. Hox11 paralogous genes are essential for metanephric kidney induction. Wellik, D.M., Hawkes, P.J., Capecchi, M.R. Genes Dev. (2002) [Pubmed]
  2. Loss of fibula in mice overexpressing Hoxc11. Papenbrock, T., Visconti, R.P., Awgulewitsch, A. Mech. Dev. (2000) [Pubmed]
  3. The mouse Hoxc11 gene: genomic structure and expression pattern. Hostikka, S.L., Capecchi, M.R. Mech. Dev. (1998) [Pubmed]
  4. The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions. Peterson, R.L., Papenbrock, T., Davda, M.M., Awgulewitsch, A. Mech. Dev. (1994) [Pubmed]
 
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