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Gene Review: 

His2  -  hematopoietic insertion site 2

Mus musculus

Synonyms: His-2
 
 
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Disease relevance of His2

  • His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia [1].
  • No recombinants were observed between His-2 and Gin-1, a common site of provirus integration in Gross passage A MuLV-induced T-cell leukemias, in 131 backcross animals, suggesting that these loci are tightly linked [1].
 

High impact information on His2

  • The ORF encodes a protein with several features characteristic of regulatory factors, including two I repeats, two leucine zippers, and a single Cys-2/His-2 zinc finger [2].
  • Genetic mapping of these loci using interspecific backcross analysis assigned the His-1 locus to mouse chromosome 2 and the His-2 locus to mouse chromosome 19 [1].
  • This analysis revealed that Lvis1 maps between two previously identified viral insertion sites, His2 and Frat1, and does not cosegregate with known gene markers [3].
  • Replacements at two other positions (His-2 and Trp-3) completely negated immunocastration activity [4].
 

Anatomical context of His2

  • Probes from one integration site (His-1) defined a region that was rearranged in 3/52 cell lines, and probes from a second integration site (His-2) identified a rearrangement in 2/52 cell lines [1].

References

  1. His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia. Askew, D.S., Bartholomew, C., Buchberg, A.M., Valentine, M.B., Jenkins, N.A., Copeland, N.G., Ihle, J.N. Oncogene (1991) [Pubmed]
  2. GTF2IRD2 is located in the Williams-Beuren syndrome critical region 7q11.23 and encodes a protein with two TFII-I-like helix-loop-helix repeats. Makeyev, A.V., Erdenechimeg, L., Mungunsukh, O., Roth, J.J., Enkhmandakh, B., Ruddle, F.H., Bayarsaihan, D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. A mouse chromosome 19 genetic map including the Lvis1 viral insertion site. Hansen, G.M., Tackles, D., Schwartz, C., Justice, M.J. Genomics (1999) [Pubmed]
  4. The role of the individual amino acids of a GnRH-tandem-dimer peptide used as an antigen for immunocastration of male piglets determined with systematic alanine replacements. Turkstra, J.A., Oonk, H.B., Schaaper, W.M., Meloen, R.H. Vaccine (2001) [Pubmed]
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