Disease relevance of Mml1

• Mml1, a new common integration site in murine leukemia virus-induced promonocytic leukemias maps to mouse chromosome 10 [1].
• Studies have focused on two genetic loci, c-myb and Mml1, whose activation by retroviral insertional mutagenesis contribute to promonocytic leukemia in our acute monocytic leukemia (AMoL) model [2].

High impact information on Mml1

• Despite its linkage to c-myb, Myb mRNA and protein expression appear to be unaffected in leukemias with Mml1 integrations [3].
• MuLV-insertional mutagenesis of c-myb and Mml1 in a murine model for promonocytic leukemia [3].
• Chromosomal mapping studies, performed using progeny from interspecies backcross mice generated by mating (BALB/cAn x M. spretus)F1 females to BALB/cAN males, determined that Mml1 is located on the proximal end of mouse chromosome 10 [1].

Biological context of Mml1

• It is anticipated that future experiments will determine whether Mml1 integration prevents down regulation of c-myb expression or activates another gene on chromosome 10 [1].

References