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Gene Review

Mml1  -  MuLV-induced myeloid leukemia 1

Mus musculus

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Disease relevance of Mml1


High impact information on Mml1

  • Despite its linkage to c-myb, Myb mRNA and protein expression appear to be unaffected in leukemias with Mml1 integrations [3].
  • MuLV-insertional mutagenesis of c-myb and Mml1 in a murine model for promonocytic leukemia [3].
  • Chromosomal mapping studies, performed using progeny from interspecies backcross mice generated by mating (BALB/cAn x M. spretus)F1 females to BALB/cAN males, determined that Mml1 is located on the proximal end of mouse chromosome 10 [1].

Biological context of Mml1


  1. Mml1, a new common integration site in murine leukemia virus-induced promonocytic leukemias maps to mouse chromosome 10. Koller, R., Krall, M., Mock, B., Bies, J., Nazarov, V., Wolff, L. Virology (1996) [Pubmed]
  2. Retroviral insertional mutagenesis in murine promonocytic leukemias: c-myb and Mml1. Wolff, L., Koller, R., Bies, J., Nazarov, V., Hoffman, B., Amanullah, A., Krall, M., Mock, B. Curr. Top. Microbiol. Immunol. (1996) [Pubmed]
  3. MuLV-insertional mutagenesis of c-myb and Mml1 in a murine model for promonocytic leukemia. Bies, J., Koller, R., Hoffman, B., Amanullah, A., Mock, B., Wolff, L. Leukemia (1997) [Pubmed]
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