The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Idd16  -  insulin dependent diabetes susceptibility 16

Mus musculus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Idd16

 

High impact information on Idd16

  • Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex [3].
  • Introduction of the H2(gx) haplotype from the related but diabetes-resistant cataract Shionogi (CTS) strain demonstrated an additional MHC-linked locus designated Idd16 [3].
  • We identified one major dominant locus, Ceat1, on chromosome 17, overlapping with Idd16 [1].
  • In the non-obese diabetic (NOD) mouse, a second component (Idd16) has been mapped to a region adjacent to, but distinct from Idd1 in the class II region [4].
  • This region on human chromosome 6 is syntenic to a part of the region adjacent to the mouse major histocompatibility complex (MHC) on chromosome 17, which has been suggested to harbor a susceptibility gene in mouse (Idd16) [5].
 

Associations of Idd16 with chemical compounds

 

Other interactions of Idd16

  • Sequence analysis of Tnf as a candidate for Idd16 [6].
  • By using a congenic NOD strain which possesses recombinant MHC from a closely related CTS strain, a susceptible region (Idd16) was mapped to the segment adjacent to, but distinct from class II A and E genes (Idd1) [6].
  • MHC-Linked Susceptibility to Type 1 Diabetes in the NOD Mouse: Further Localization of Idd16 by Subcongenic Analysis [7].

References

  1. An interval tightly linked to but distinct from the H2 complex controls both overt diabetes (Idd16) and chronic experimental autoimmune thyroiditis (Ceat1) in nonobese diabetic mice. Boulard, O., Damotte, D., Deruytter, N., Fluteau, G., Carnaud, C., Garchon, H.J. Diabetes (2002) [Pubmed]
  2. Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping. Ikegami, H., Makino, S., Yamato, E., Kawaguchi, Y., Ueda, H., Sakamoto, T., Takekawa, K., Ogihara, T. J. Clin. Invest. (1995) [Pubmed]
  3. Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex. Pomerleau, D.P., Bagley, R.J., Serreze, D.V., Mathews, C.E., Leiter, E.H. Diabetes (2005) [Pubmed]
  4. Allelic variation in class I K gene as candidate for a second component of MHC-linked susceptibility to type 1 diabetes in non-obese diabetic mice. Inoue, K., Ikegami, H., Fujisawa, T., Noso, S., Nojima, K., Babaya, N., Itoi-Babaya, M., Makimo, S., Ogihara, T. Diabetologia (2004) [Pubmed]
  5. No evidence of type 1 diabetes susceptibility genes in the region centromeric of the HLA complex. Johansson, S., Lie, B.A., Cambon-Thomsen, A., Pociot, F., Nerup, J., Kockum, I., Thorsby, E., Undlien, D.E. Hum. Immunol. (2003) [Pubmed]
  6. Sequence analysis of Tnf as a candidate for Idd16. Babaya, N., Ikegami, H., Fujisawa, T., Ueda, H., Nojima, K., Itoi-Babaya, M., Yamada, K., Kawaguchi, Y., Yamato, E., Makino, S., Ogihara, T. Autoimmunity (2002) [Pubmed]
  7. MHC-Linked Susceptibility to Type 1 Diabetes in the NOD Mouse: Further Localization of Idd16 by Subcongenic Analysis. Fujisawa, T., Ikegami, H., Noso, S., Yamaji, K., Nojima, K., Babaya, N., Itoi-Babaya, M., Hiromine, Y., Kobayashi, M., Makino, S., Ogihara, T. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
 
WikiGenes - Universities