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Gene Review:

H2-D - histocompatibility 2, D region

Mus musculus

Lambracht-Washington, D. et al., Southern, S.O. et al., Pomerleau, D.P. et al.

Lambracht-Washington, Fischer Lindahl,

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High impact information on H2-D

Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex [1].
In T cells, a similar elevation of H-2 D expression occurred after stimulation with IL-5 or Con A [2].
Expression of the H-2 D protein was increased over 10-fold in B cells activated by IL-4 IL-5, IFN-gamma or LPS [2].
The enhancement of H-2 D expression on activated B cells was regulated at the transcriptional level and required synthesis of an intermediate cellular protein(s) [2].
The class I gene RT1.46 (l) has an open reading frame, but it is unlike H2-D due to a unique 5'UTR shared with H2-Q1 and Q2, the absence of the B2 SINE repeat characteristic of H2-D/L, and the apparent lack of surface expression [3].

Biological context of H2-D

Downstream of Bat1 is a sequence stretch with great similarity to intron 3 of H2-D, which is not present in any of the rat class I genes but is found in mouse H2-K, D-, and - Q region genes [3].

References

Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex. Pomerleau, D.P., Bagley, R.J., Serreze, D.V., Mathews, C.E., Leiter, E.H. Diabetes (2005) [Pubmed]
A role for class I MHC antigens in responses of activated B lymphocytes. Southern, S.O., Dutton, R.W. J. Immunol. (1989) [Pubmed]
Does the rat have an H2-D orthologue next to Bat1? Lambracht-Washington, D., Fischer Lindahl, K. Immunogenetics (2002) [Pubmed]

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