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Gene Review

lacR  -  lactose transport regulator

Lactococcus lactis subsp. lactis Il1403

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Disease relevance of lacR


High impact information on lacR

  • Transcription of lacR, into a 1.2-kilobase monocistronic messenger, is repressed approximately 5-fold during growth on lactose [1].
  • The presence of lacR on a multicopy plasmid resulted in the decrease of lactose phosphotransferase system activity, whereas only on lactose a decrease (25%) of growth rate was observed [1].
  • Nucleotide sequence analysis of the lacR gene showed the presence of an open reading frame of 861 base pairs [1].
  • In vivo bioluminescence assays demonstrated that lacR negatively regulates the lac operon and also autoregulates itself [2].
  • Genes for the lactose-specific PEP-PTS proteins, phospho-beta-galactosidase and tagatose 6-phosphate pathway enzymes are encoded by a single 8 kb operon, lacABCDFEGX, and there is a divergently transcribed lacR repressor gene [2].

Biological context of lacR

  • The lacR promoter was demonstrated to be a particularly strong promoter, being approximately four times more efficient than the lac operon promoter [2].


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