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Gene Review:

Ifna - interferon alpha

Mus musculus

Synonyms: Ifa, Ifa8

Bluyssen, H.A. et al., Okumoto, M. et al., Okumoto, M. et al., Fultz, M.J. et al., Wiseman, R.W. et al., et al.

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Disease relevance of Ifna

The phage inserts contained overlapping genomic fragments which span a total length of approx. 30 kb, on which four Ha Ifa genes are localized [1].
There was obvious difference between the patterns in the region containing the Ifa locus on chromosome 4 which has been shown to be related to the incidence of radiation-induced lymphomas [2].

High impact information on Ifna

Analysis of nine chromosome 4 loci defined an interstitial deletion containing the Ifa gene cluster in one of the lung tumors [3].
Therefore, we conclude that the Lps and the Ifa genes are physically distinct despite the apparent cause and effect relationship which is observed phenotypically [4].
The Ifa gene cluster could be assigned to hamster chromosome 2q [1].
Three recombinant phages containing hamster interferon-alpha-encoding genes (Ha Ifa) were isolated from a Ha genomic library, using a murine (Mu) Ifa probe [1].
ADRP has been mapped to chromosome 4, specifically between the b and Ifa loci [5].

Biological context of Ifna

The best concordances between strain distribution patterns of genetic markers and resistance (or susceptibility) to radiation lymphomagenesis were observed in a region with the b and Ifa genes on chromosome 4 [6].

Other interactions of Ifna

This analysis positions the mea phenotypic locus in the interval between Ifa and Glut1 [7].
Available genetic information places the mouse db gene approximately 5 cM distal to Ifa on mid/distal mouse chromosome 4 [8].

Analytical, diagnostic and therapeutic context of Ifna

The mouse IFN-alpha (Ifa) locus: correlation of physical and linkage maps by in situ hybridization [9].

References

Isolation, properties and chromosomal localization of four closely linked hamster interferon-alpha-encoding genes. Bluyssen, H.A., Nakamura, N., Vlietstra, R.J., Smit, E.M., Hagemeijer, A., Trapman, J. Gene (1995) [Pubmed]
Genetic control of the radiosensitivity of lymphoid cells for antibody formation ability in mice. Okumoto, M., Mori, N., Imai, S., Haga, S., Hilgers, J., Takamori, Y., Esaki, K. J. Radiat. Res. (1994) [Pubmed]
Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes. Wiseman, R.W., Cochran, C., Dietrich, W., Lander, E.S., Söderkvist, P. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
The physical separation of Lps and Ifa loci in BXH recombinant inbred mice. Fultz, M.J., Vogel, S.N. J. Immunol. (1989) [Pubmed]
Structure of the gene encoding mouse adipose differentiation-related protein (ADRP). Eisinger, D.P., Serrero, G. Genomics (1993) [Pubmed]
Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice. Okumoto, M., Nishikawa, R., Imai, S., Hilgers, J. Cancer Res. (1990) [Pubmed]
Genetic mapping of meander tail, a mouse mutation affecting cerebellar development. Fletcher, C., Norman, D.J., Heintz, N. Genomics (1991) [Pubmed]
Microdissection and microcloning of mid-chromosome 4: genetic mapping of 41 microdissection clones. Bahary, N., McGraw, D.E., Shilling, R., Friedman, J.M. Genomics (1993) [Pubmed]
The mouse IFN-alpha (Ifa) locus: correlation of physical and linkage maps by in situ hybridization. Cheng, Z.Y., Lovett, M., Epstein, L.B., Epstein, C.J. Cytogenet. Cell Genet. (1986) [Pubmed]

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