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Gene Review

Slc2a1  -  solute carrier family 2 (facilitated...

Mus musculus

Synonyms: GLUT-1, GT1, Glucose transporter type 1, erythrocyte/brain, Glut-1, Glut1, ...
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Disease relevance of Slc2a1

  • Hypoxia inducible factor (HIF)-1alpha and Glucose Transporter 1 (Glut-1) levels were determined by Western blot [1].
  • In vivo hyperglycemia and its effect on Glut-1 expression in the embryonic heart [2].
  • This increase in glucose transport was not associated with a change in transporter affinity for glucose, but increased Glut-1 expression was observed indicating a 'heat stress' effect that overrode the effects attributable to oncogene loss [3].
  • The GT1 strain (inducing 100% mortality at day 9) also gave the fastest response in terms of weight loss (onset by day 8) and increase in serum haptoglobin (onset by day 6), which occurred 1-2 days before these parameters were affected in the other low-dose groups [4].

High impact information on Slc2a1


Biological context of Slc2a1


Anatomical context of Slc2a1

  • While both transporters were expressed in the amnion and chorion, only Glut-1 was expressed in the ectoplacental cone [8].
  • METHODS: The rate of 2-deoxyglucose uptake was measured in Xenopus laevis oocytes heterologously expressing mammalian Glut isoforms [12].
  • GT1 mRNA is most abundant in mouse brain and is expressed in both 3T3-L1 preadipocytes and adipocytes [10].
  • One of these cDNAs encodes the murine homolog of the human hepG2/erythrocyte glucose transporter, termed GT1 [10].
  • In addition, our data indicate that the restriction of Glut 1 expression to the intraneural capillaries reflects the onset of bbb function in the mouse embryo [13].

Associations of Slc2a1 with chemical compounds


Other interactions of Slc2a1

  • The differentially expressed cDNA clones represent mouse Glut-1 and Glut-3 [8].
  • We found that Glut1 transcription was also increased by ET-1 and cAMP in a synergistic fashion [9].
  • Glut-1 expression was increased in WT and eNOS KO mice [1].
  • Furthermore, PMA was found to act synergistically with 8-bromo cAMP to induce Glut1 transcription and ET-1 was shown to activate novel PKCdelta and PKC [9].
  • Glut1/HK1 cells accumulated Glut1 on the cell surface and had high glucose uptake capacity similar to that of cells with constitutively active Akt (mAkt) [11].

Analytical, diagnostic and therapeutic context of Slc2a1

  • Glut 1 immunofluorescence staining was done on cryosections using a rabbit polyclonal antiserum to purified human erythrocyte glucose transporter [13].
  • Glut-1, HKI, and GRP78 protein levels were determined by Western analysis, and Glut-1 mRNA was measured by RT-PCR [14].
  • Embryos were examined for morphology and total cardiac protein, and embryonic hearts were evaluated for Glut-1 protein and mRNA expression immediately after treatment (GD 9.75, GD 10.0), as well as on GD 10.5 and GD 12 [2].


  1. Endothelially derived nitric oxide affects the severity of early acetaminophen-induced hepatic injury in mice. Salhanick, S.D., Orlow, D., Holt, D.E., Pavlides, S., Reenstra, W., Buras, J.A. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. (2006) [Pubmed]
  2. In vivo hyperglycemia and its effect on Glut-1 expression in the embryonic heart. Joyner, N.T., Smoak, I.W. Birth defects research. Part A, Clinical and molecular teratology. (2004) [Pubmed]
  3. Transforming oncogenes regulate glucose transport by increasing transporter affinity for glucose: contrasting effects of oncogenes and heat stress in a murine marrow-derived cell line. Ahmed, N., Berridge, M.V. Life Sci. (1998) [Pubmed]
  4. A study of virulence parameters for Toxoplasma gondii infections in mice. Jensen, L., Heegaard, P.M., Lind, P. Parasitol. Res. (1998) [Pubmed]
  5. Diverse effects of Glut 4 ablation on glucose uptake and glycogen synthesis in red and white skeletal muscle. Stenbit, A.E., Burcelin, R., Katz, E.B., Tsao, T.S., Gautier, N., Charron, M.J., Le Marchand-Brustel, Y. J. Clin. Invest. (1996) [Pubmed]
  6. Insulin unmasks a COOH-terminal Glut4 epitope and increases glucose transport across T-tubules in skeletal muscle. Wang, W., Hansen, P.A., Marshall, B.A., Holloszy, J.O., Mueckler, M. J. Cell Biol. (1996) [Pubmed]
  7. NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. Belsham, D.D., Wetsel, W.C., Mellon, P.L. EMBO J. (1996) [Pubmed]
  8. Differential screening of a PCR-generated mouse embryo cDNA library: glucose transporters are differentially expressed in early postimplantation mouse embryos. Smith, D.E., Gridley, T. Development (1992) [Pubmed]
  9. Synergistic effect of endothelin-1 and cyclic AMP on glucose transport in 3T3-L1 adipocytes. Fong, J.C., Kao, Y.S., Tsai, H.Y., Chiou, Y.Y., Chiou, G.Y. Cell. Signal. (2004) [Pubmed]
  10. Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes. Kaestner, K.H., Christy, R.J., McLenithan, J.C., Braiterman, L.T., Cornelius, P., Pekala, P.H., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  11. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Rathmell, J.C., Fox, C.J., Plas, D.R., Hammerman, P.S., Cinalli, R.M., Thompson, C.B. Mol. Cell. Biol. (2003) [Pubmed]
  12. Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations. Murata, H., Hruz, P.W., Mueckler, M. AIDS (2002) [Pubmed]
  13. Ontogenic expression of the erythroid-type glucose transporter (Glut 1) in the telencephalon of the mouse: correlation to the tightening of the blood-brain barrier. Bauer, H., Sonnleitner, U., Lametschwandtner, A., Steiner, M., Adam, H., Bauer, H.C. Brain Res. Dev. Brain Res. (1995) [Pubmed]
  14. Tolbutamide alters glucose transport and metabolism in the embryonic mouse heart. Smoak, I.W. Teratology (2002) [Pubmed]
  15. Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP. Hresko, R.C., Heimberg, H., Chi, M.M., Mueckler, M. J. Biol. Chem. (1998) [Pubmed]
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