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Gene Review

Plin2  -  perilipin 2

Mus musculus

Synonyms: AA407157, ADPH, ADRP, Adfp, Adipophilin, ...
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Disease relevance of Adfp


High impact information on Adfp


Chemical compound and disease context of Adfp

  • In the present paper, the murine ADRP has been expressed as a recombinant histidine-tagged protein in Escherichia coli, and purified from expressing cultures in order to examine its biochemical properties [4].

Biological context of Adfp


Anatomical context of Adfp

  • Given that lipid droplets are thought to form from the outer leaflet of the microsomal membrane, the reduction of TG in the cytosol with concomitant accumulation of TG in the microsome of Adfp-/- cells suggests that ADFP may facilitate the formation of new LDs [2].
  • ADRP, proposed to regulate fatty acid mobilization and lipid droplet formation, is linked to lipid accumulation in foam cells of human atherosclerotic lesions [14].
  • In this report, we show that ADRP protein accumulates in Chinese hamster ovary fibroblastic cells cultured in the presence of oleic acid but is destabilized when fatty acid sources are removed from culture serum [14].
  • This finding was confirmed at the protein level by Western blotting, and immunohistochemistry localized ADRP diffusely to tubular epithelium throughout the cortex [11].
  • ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts [15].

Associations of Adfp with chemical compounds

  • Overexpressed GFP-ADRP were mainly located at the surface of lipid droplets and appeared to be "ring-shaped." Triacylglycerol content was also significantly (P < 0.001) increased in GFP-ADRP-overexpressed cells compared with control cells [15].
  • Expression and localization of adipophilin and perilipin in human fetal membranes: association with lipid bodies and enzymes involved in prostaglandin synthesis [12].
  • The present study showed that the GDP-bound ARF1 induces dissociation of ADRP from the LD surface, and that LD is a target of BFA action [16].
  • Displacement studies showed differential binding affinity of ADRP for cholesterol and fatty acids [17].
  • The oleate uptake measured at 4 degrees C was only 10% that at 37 degrees C. ADRP also stimulated uptake of palmitate and arachidonate but had no effect on uptake of medium chain fatty acid such as octanoic acid and glucose [18].

Regulatory relationships of Adfp


Other interactions of Adfp


Analytical, diagnostic and therapeutic context of Adfp


  1. Structure of the gene encoding mouse adipose differentiation-related protein (ADRP). Eisinger, D.P., Serrero, G. Genomics (1993) [Pubmed]
  2. Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein. Chang, B.H., Li, L., Paul, A., Taniguchi, S., Nannegari, V., Heird, W.C., Chan, L. Mol. Cell. Biol. (2006) [Pubmed]
  3. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. Brasaemle, D.L., Barber, T., Wolins, N.E., Serrero, G., Blanchette-Mackie, E.J., Londos, C. J. Lipid Res. (1997) [Pubmed]
  4. Adipose differentiation related protein: expression, purification of recombinant protein in Escherichia coli and characterization of its fatty acid binding properties. Serrero, G., Frolov, A., Schroeder, F., Tanaka, K., Gelhaar, L. Biochim. Biophys. Acta (2000) [Pubmed]
  5. The Cys214-->Ser mutation in peripherin/rds causes a loss-of-function phenotype in transgenic mice. Stricker, H.M., Ding, X.Q., Quiambao, A., Fliesler, S.J., Naash, M.I. Biochem. J. (2005) [Pubmed]
  6. Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. Imanishi, Y., Gerke, V., Palczewski, K. J. Cell Biol. (2004) [Pubmed]
  7. Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. Imanishi, Y., Batten, M.L., Piston, D.W., Baehr, W., Palczewski, K. J. Cell Biol. (2004) [Pubmed]
  8. Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Greenberg, A.S., Egan, J.J., Wek, S.A., Moos, M.C., Londos, C., Kimmel, A.R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  9. Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses. Beier, D.R., Dushkin, H., Sussman, D.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  10. CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. Yamaguchi, T., Omatsu, N., Matsushita, S., Osumi, T. J. Biol. Chem. (2004) [Pubmed]
  11. Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney. Mishra, R., Emancipator, S.N., Miller, C., Kern, T., Simonson, M.S. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  12. Expression and localization of adipophilin and perilipin in human fetal membranes: association with lipid bodies and enzymes involved in prostaglandin synthesis. Meadows, J.W., Pitzer, B., Brockman, D.E., Myatt, L. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  13. Temporal and spatial assembly of lipid droplet-associated proteins in 3T3-L1 preadipocytes. Wang, S.M., Hwang, R.D., Greenberg, A.S., Yeo, H.L. Histochem. Cell Biol. (2003) [Pubmed]
  14. Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway. Xu, G., Sztalryd, C., Lu, X., Tansey, J.T., Gan, J., Dorward, H., Kimmel, A.R., Londos, C. J. Biol. Chem. (2005) [Pubmed]
  15. ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts. Imamura, M., Inoguchi, T., Ikuyama, S., Taniguchi, S., Kobayashi, K., Nakashima, N., Nawata, H. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  16. ADRP is dissociated from lipid droplets by ARF1-dependent mechanism. Nakamura, N., Akashi, T., Taneda, T., Kogo, H., Kikuchi, A., Fujimoto, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  17. Sterol carrier protein-2 expression modulates protein and lipid composition of lipid droplets. Atshaves, B.P., Storey, S.M., McIntosh, A.L., Petrescu, A.D., Lyuksyutova, O.I., Greenberg, A.S., Schroeder, F. J. Biol. Chem. (2001) [Pubmed]
  18. Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake. Gao, J., Serrero, G. J. Biol. Chem. (1999) [Pubmed]
  19. Arf1-dependent PLD1 is localized to oleic acid-induced lipid droplets in NIH3T3 cells. Nakamura, N., Banno, Y., Tamiya-Koizumi, K. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  20. Lipid droplet targeting domains of adipophilin. McManaman, J.L., Zabaronick, W., Schaack, J., Orlicky, D.J. J. Lipid Res. (2003) [Pubmed]
  21. Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. Dalen, K.T., Schoonjans, K., Ulven, S.M., Weedon-Fekjaer, M.S., Bentzen, T.G., Koutnikova, H., Auwerx, J., Nebb, H.I. Diabetes (2004) [Pubmed]
  22. Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Jiang, H.P., Serrero, G. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  23. PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. Schadinger, S.E., Bucher, N.L., Schreiber, B.M., Farmer, S.R. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  24. Magnolol stimulates lipolysis in lipid-laden RAW 264.7 macrophages. Chen, J.S., Chen, Y.L., Greenberg, A.S., Chen, Y.J., Wang, S.M. J. Cell. Biochem. (2005) [Pubmed]
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