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Gene Review:

FAM107A - family with sequence similarity 107, member A

Homo sapiens

Synonyms: DRR1, Down-regulated in renal cell carcinoma 1, Protein FAM107A, Protein TU3A, TU3A

Kholodnyuk, I.D. et al., Wang, L. et al., van den Boom, J. et al.

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Disease relevance of FAM107A

Loss of expression of the DRR 1 gene at chromosomal segment 3p21.1 in renal cell carcinoma [1].
In addition, AMOG, DRR1 and PSD3 transcript levels were significantly lower in primary glioblastomas than in diffuse astrocytomas [2].
Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice [3].

High impact information on FAM107A

Expression of the down-regulated in renal cell carcinoma gene (DRR1) gene at 3p14.2 was lost in 7 and down regulated in 2 "chr3+" tumours [3].
We also transfected the gene into DRR 1-negative cell lines and observed clear growth retardation [1].
1. In our search for tumor suppressor genes from this region, we have cloned a gene that we have called DRR 1 (downregulated in renal cell carcinoma) [1].

References

Loss of expression of the DRR 1 gene at chromosomal segment 3p21.1 in renal cell carcinoma. Wang, L., Darling, J., Zhang, J.S., Liu, W., Qian, J., Bostwick, D., Hartmann, L., Jenkins, R., Bardenhauer, W., Schutte, J., Opalka, B., Smith, D.I. Genes Chromosomes Cancer (2000) [Pubmed]
Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction. van den Boom, J., Wolter, M., Blaschke, B., Knobbe, C.B., Reifenberger, G. Int. J. Cancer (2006) [Pubmed]
Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. Kholodnyuk, I.D., Kozireva, S., Kost-Alimova, M., Kashuba, V., Klein, G., Imreh, S. Int. J. Cancer (2006) [Pubmed]

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