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Gene Review

PRAF2  -  PRA1 domain family, member 2

Homo sapiens

Synonyms: JM4, PRA1 family protein 2
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Disease relevance of PRAF2

  • Elevated PRAF2 expression levels correlated with unfavorable genetic and clinical features, suggesting PRAF2 as a candidate prognostic marker of neuroblastoma [1].

High impact information on PRAF2

  • Our studies show for the first time that the CCR5-interacting PRAF2 protein is expressed in several human tissues with a possible function in ER/Golgi transport and vesicular traffic [2].
  • The human PRAF2 gene contains three exons separated by two introns and is located on human chromosome Xp11.23 [2].
  • PRAF2 (formerly designated JM4) belongs to a new protein family, which plays a role in the regulation of intracellular protein transport [2].
  • The recombinant PRAF2 protein was readily expressed in Schneider 2 (S2) insect cells, and the native protein was detected in human tissues with strong expression in the brain, small intestine, lung, spleen, and pancreas [2].
  • Furthermore, JM4, JWA, and GTRAP3-18 co-localise and heterodimerise indicating a functional relationship [3].

Biological context of PRAF2


Anatomical context of PRAF2


Other interactions of PRAF2

  • JM4 is membrane-associated, co-precipitates with CCR5, and is ubiquitously expressed [3].


  1. Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation. Geerts, D., Wallick, C.J., Koomoa, D.L., Koster, J., Versteeg, R., Go, R.C., Bachmann, A.S. Clin. Cancer Res. (2007) [Pubmed]
  2. Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). Fo, C.S., Coleman, C.S., Wallick, C.J., Vine, A.L., Bachmann, A.S. Gene (2006) [Pubmed]
  3. JM4 is a four-transmembrane protein binding to the CCR5 receptor. Schweneker, M., Bachmann, A.S., Moelling, K. FEBS Lett. (2005) [Pubmed]
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