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Gene Review

ARL6IP5  -  ADP-ribosylation factor-like 6 interacting...

Homo sapiens

Synonyms: ADP-ribosylation factor-like protein 6-interacting protein 5, ARL-6-interacting protein 5, Aip-5, Cytoskeleton-related vitamin A-responsive protein, DERP11, ...
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Disease relevance of ARL6IP5

  • For the notable performance achieved by ATRA in the differentiation induction therapy, we investigated the role of JWA in the induction of differentiation of human myeloid leukemia cells [1].

High impact information on ARL6IP5

  • Moreover, the introduction of a di-acidic motif to the COOH-terminal domain of PRA2 resulted in partial localization to the Golgi complex [2].
  • The two PRA isoforms showed distinct intracellular localization with PRA1 localized primarily to the Golgi complex and PRA2 to the endoplasmic reticulum (ER) compartment [2].
  • Using phytochrome-deficient mutants, we showed that the pra2 protein level in seedlings was also regulated by these photoreceptors [3].
  • Using this construct in a transient assay, we determined a pra2 cis-regulatory region sufficient to direct the light down-regulation of the luciferase reporter gene [4].
  • Furthermore, JM4, JWA, and GTRAP3-18 co-localise and heterodimerise indicating a functional relationship [5].

Chemical compound and disease context of ARL6IP5

  • Our results showed that JWA was not only regulated by ATRA but also by several other differentiation inducers such as phorbol-12-myristate-13-acetate (TPA), arabinoside (Ara-C), and hemin, involved in the mechanisms of differentiation along different lineages of myeloid leukemia cells arrested at different stages of development [1].

Biological context of ARL6IP5

  • Inhibition of JWA by RNA interference decreased the induced cellular differentiation [1].
  • Our recent data showed that JWA, initially being cloned as a novel cell differentiation-associated gene, was also actively responsive to environmental stressors, such as heat-shock, oxidative stress and so on [6].
  • In the present study, we have applied a modified comet assay and bacterial repair endonucleases system (endonuclease III and formamidopyrimidine glycosylase) to investigate if JWA is involved in hydrogen peroxide (H2O2)-induced DNA damage and repair in K562 and MCF-7 cells, and to demonstrate if the damage is associated with 8-oxo-dG [6].
  • In addition, the data have clearly demonstrated that JWA gene expression is actively induced by H2O2 treatment in K562 and MCF-7 cells [6].
  • 5. These data indicate that the inhibition of proliferation and the induction of apoptosis by ATRA are dependent on JWA expression in HeLa cells [7].

Anatomical context of ARL6IP5

  • JM4 and GTRAP3-18 harbor a Rab-acceptor motif, indicating a function in vesicle formation at the Golgi complex [5].
  • JWA (AF070523) is a novel all-trans retinoic acid (ATRA) responsible gene that initially isolated from ATRA-treated primary human tracheal bronchial epithelial cells [1].
  • In NB4 cells, JWA may function as a lineage-restricted gene during differentiation along the monocyte/macrophage-like or granulocytic pathway [1].
  • In JWA-overexpressing HeLa cells, ATRA showed more significant antiproliferative effects and induced more apoptosis [7].
  • JWA may be a novel molecular marker for ATRA-induced HL-60 cell differentiation [8].

Associations of ARL6IP5 with chemical compounds


Analytical, diagnostic and therapeutic context of ARL6IP5

  • The changes in the immunoblotting pattern of the pra2 protein in these mutants were correlated with the changes in epicotyl elongation [3].
  • Northern blot analysis showed mRNA corresponding to hp22 to be expressed in all tissues examined [13].
  • We also found that protein interaction with PRA2 is highly sensitive to detergent and describe a covalent cross-linking procedure for mammalian cell extracts to stabilize the PRA2-containing complex prior to membrane solubilization and immunoprecipitation [9].


  1. JWA, a novel signaling molecule, involved in the induction of differentiation of human myeloid leukemia cells. Huang, S., Shen, Q., Mao, W.G., Li, A.P., Ye, J., Liu, Q.Z., Zou, C.P., Zhou, J.W. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  2. PRA isoforms are targeted to distinct membrane compartments. Abdul-Ghani, M., Gougeon, P.Y., Prosser, D.C., Da-Silva, L.F., Ngsee, J.K. J. Biol. Chem. (2001) [Pubmed]
  3. DE1, a 12-base pair cis-regulatory element sufficient to confer dark-inducible and light down-regulated expression to a minimal promoter in pea. Inaba, T., Nagano, Y., Reid, J.B., Sasaki, Y. J. Biol. Chem. (2000) [Pubmed]
  4. Identification of a cis-regulatory element involved in phytochrome down-regulated expression of the pea small GTPase gene pra2. Inaba, T., Nagano, Y., Sakakibara, T., Sasaki, Y. Plant Physiol. (1999) [Pubmed]
  5. JM4 is a four-transmembrane protein binding to the CCR5 receptor. Schweneker, M., Bachmann, A.S., Moelling, K. FEBS Lett. (2005) [Pubmed]
  6. Regulation of a novel cell differentiation-associated gene, JWA during oxidative damage in K562 and MCF-7 cells. Zhu, T., Chen, R., Li, A.P., Liu, J., Liu, Q.Z., Chang, H.C., Zhou, J.W. J. Biomed. Sci. (2005) [Pubmed]
  7. JWA is required for the antiproliferative and pro-apoptotic effects of all-trans retinoic acid in Hela cells. Mao, W.G., Liu, Z.L., Chen, R., Li, A.P., Zhou, J.W. Clin. Exp. Pharmacol. Physiol. (2006) [Pubmed]
  8. JWA, a novel signaling molecule, involved in all-trans retinoic acid induced differentiation of HL-60 cells. Huang, S., Shen, Q., Mao, W.G., Li, A.P., Ye, J., Liu, Q.Z., Zou, C.P., Zhou, J.W. J. Biomed. Sci. (2006) [Pubmed]
  9. Purification and functional properties of prenylated Rab acceptor 2. Gougeon, P.Y., Ngsee, J.K. Meth. Enzymol. (2005) [Pubmed]
  10. JWA as a novel molecule involved in oxidative stress-associated signal pathway in myelogenous leukemia cells. Zhu, T., Chen, R., Li, A., Liu, J., Gu, D., Liu, Q., C Chang, H., Zhou, J. J. Toxicol. Environ. Health Part A (2006) [Pubmed]
  11. JWA--a novel environmental-responsive gene, involved in estrogen receptor-associated signal pathway in MCF-7 and MDA-MB-231 breast carcinoma cells. Chen, R., Li, A., Zhu, T., Li, C., Liu, Q., Chang, H.C., Zhou, J. J. Toxicol. Environ. Health Part A (2005) [Pubmed]
  12. Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension. Franchi, F., Lo Sapio, P., Strazzulla, G., Fabbri, G., Scardi, A., Pinzani, M., Laffi, G., Mannelli, M. International journal of clinical pharmacology, therapy, and toxicology. (1987) [Pubmed]
  13. Isolation and characterization of a cDNA encoding a novel human transcription factor TFIID subunit containing similarities with histones H2B and H3. Choi, B.I., Bando, M., Hasegawa, S., Horikoshi, M. Gene (1996) [Pubmed]
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