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Gene Review

TP53TG1  -  TP53 target 1 (non-protein coding)

Homo sapiens

Synonyms: H_RG012D21.9, LINC00096, NCRNA00096, P53TG1, P53TG1-D, ...
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Disease relevance of TP53AP1


High impact information on TP53AP1

  • Both types of transcripts are detected in various normal human tissues with a predominance for exon 1b containing transcripts and are up-regulated by TP53, confirming that HIC-1 is a TP53 target gene [2].
  • Here we report isolation and characterization of a novel TP53-inducible gene, termed TP53TG3 (TP53 target gene 3) [3].
  • Under conditions of cellular stress (ultraviolet irradiation or exposure to bleomycin or cisplatin), expression of TP53TG1 was induced in a wild-type TP53-dependent manner, indicating that this gene is likely to play an important role in the signaling pathway of TP53 and may function in response to cellular damage [1].
  • The cDNA, termed TP53TG1 (TP53 target gene 1), contained an open reading frame of 270 nucleotides encoding 90 amino acids [1].
  • To understand the potential mechanism(s) by which TP53 inhibits PD0166285-induced G(2)-phase checkpoint abrogation, two TP53 target proteins, 14-3-3rho and CDKN1A (also known as p21), that are known to be involved in G(2)-phase checkpoint control in other cell models were examined [4].

Associations of TP53AP1 with chemical compounds


  1. Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild-type TP53 expression system. Takei, Y., Ishikawa, S., Tokino, T., Muto, T., Nakamura, Y. Genes Chromosomes Cancer (1998) [Pubmed]
  2. Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53. Guerardel, C., Deltour, S., Pinte, S., Monte, D., Begue, A., Godwin, A.K., Leprince, D. J. Biol. Chem. (2001) [Pubmed]
  3. Isolation and characterization of a novel TP53-inducible gene, TP53TG3. Ng, C.C., Koyama, K., Okamura, S., Kondoh, H., Takei, Y., Nakamura, Y. Genes Chromosomes Cancer (1999) [Pubmed]
  4. Wild-type TP53 inhibits G(2)-phase checkpoint abrogation and radiosensitization induced by PD0166285, a WEE1 kinase inhibitor. Li, J., Wang, Y., Sun, Y., Lawrence, T.S. Radiat. Res. (2002) [Pubmed]
  5. Codon 249 of the human TP53 tumor suppressor gene is no hot spot for aflatoxin B1 in a heterologous background. Sengstag, C., Mörbe, J.L., Weibel, B. Mutat. Res. (1999) [Pubmed]
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