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Gene Review

Sstr1  -  somatostatin receptor 1

Rattus norvegicus

Synonyms: SRIF-2, SS-1-R, SS1-R, SS1R, Somatostatin receptor type 1
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Disease relevance of Sstr1


Psychiatry related information on Sstr1


High impact information on Sstr1


Chemical compound and disease context of Sstr1


Biological context of Sstr1


Anatomical context of Sstr1


Associations of Sstr1 with chemical compounds


Physical interactions of Sstr1


Enzymatic interactions of Sstr1


Regulatory relationships of Sstr1


Other interactions of Sstr1


Analytical, diagnostic and therapeutic context of Sstr1


  1. The POU domain transcription factor Tst-1 activates somatostatin receptor 1 gene expression in pancreatic beta -cells. Baumeister, H., Meyerhof, W. J. Biol. Chem. (2000) [Pubmed]
  2. Both overlapping and distinct signaling pathways for somatostatin receptor subtypes SSTR1 and SSTR2 in pituitary cells. Chen, L., Fitzpatrick, V.D., Vandlen, R.L., Tashjian, A.H. J. Biol. Chem. (1997) [Pubmed]
  3. Somatostatin receptor gene therapy combined with targeted therapy with radiolabeled octreotide: a new treatment for liver metastases. Mearadji, A., Breeman, W., Hofland, L., van Koetsveld, P., Marquet, R., Jeekel, J., Krenning, E., van Eijck, C. Ann. Surg. (2002) [Pubmed]
  4. 17-beta-estradiol-dependent regulation of somatostatin receptor subtype expression in the 7315b prolactin secreting rat pituitary tumor in vitro and in vivo. Visser-Wisselaar, H.A., Van Uffelen, C.J., Van Koetsveld, P.M., Lichtenauer-Kaligis, E.G., Waaijers, A.M., Uitterlinden, P., Mooy, D.M., Lamberts, S.W., Hofland, L.J. Endocrinology (1997) [Pubmed]
  5. Regulation of galanin gene expression in the rat anterior pituitary gland by the somatostatin analog SMS 201-995. Hyde, J.F., Howard, G. Endocrinology (1992) [Pubmed]
  6. Food deprivation enhances somatostatin and somatostatin receptor subtype expression in rat colon. Kido, T., Sumii, K., Kawano, M., Sumii, M., Yoshihara, M., Chayama, K. Regul. Pept. (2003) [Pubmed]
  7. Two types of somatostatin receptors differentiated by cyclic somatostatin analogs. Tran, V.T., Beal, M.F., Martin, J.B. Science (1985) [Pubmed]
  8. Somatostatin suppresses endothelin-1-induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1. Reynaert, H., Vaeyens, F., Qin, H., Hellemans, K., Chatterjee, N., Winand, D., Quartier, E., Schuit, F., Urbain, D., Kumar, U., Patel, Y.C., Geerts, A. Gastroenterology (2001) [Pubmed]
  9. Distribution of somatostatin receptor messenger RNAs in the rat gastrointestinal tract. Krempels, K., Hunyady, B., O'Carroll, A.M., Mezey, E. Gastroenterology (1997) [Pubmed]
  10. Somatostatin receptor subtype 2 mediates somatostatin inhibition of ion secretion in rat distal colon. Warhurst, G., Higgs, N.B., Fakhoury, H., Warhurst, A.C., Garde, J., Coy, D.H. Gastroenterology (1996) [Pubmed]
  11. The somatostatin receptor subtype on rat enterochromaffinlike cells. Prinz, C., Sachs, G., Walsh, J.H., Coy, D.H., Wu, S.V. Gastroenterology (1994) [Pubmed]
  12. Somatostatin receptor subtypes SSTR2 and SSTR5 couple negatively to an L-type Ca2+ current in the pituitary cell line AtT-20. Tallent, M., Liapakis, G., O'Carroll, A.M., Lolait, S.J., Dichter, M., Reisine, T. Neuroscience (1996) [Pubmed]
  13. Time-dependent influence of the somatostatin analogue octreotide on the proliferation of rat astrocytes and glioma cells. Feindt, J., Mentlein, R., Krisch, B. Brain Res. (1997) [Pubmed]
  14. Effect of endothelial and adventitial injury on somatostatin receptor expression. Curtis, S.B., Chen, J.C., Winkelaar, G., Turnbull, R.G., Hewitt, J., Buchan, A.M., Hsiang, Y.N. Surgery (2000) [Pubmed]
  15. Fasting-induced changes in the hypothalamic-pituitary-GH axis in the absence of GH expression: lessons from the spontaneous dwarf rat. Park, S., Sohn, S., Kineman, R.D. J. Endocrinol. (2004) [Pubmed]
  16. Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway. Price, L.A., Kajkowski, E.M., Hadcock, J.R., Ozenberger, B.A., Pausch, M.H. Mol. Cell. Biol. (1995) [Pubmed]
  17. Agonist-induced desensitization, internalization, and phosphorylation of the sst2A somatostatin receptor. Hipkin, R.W., Friedman, J., Clark, R.B., Eppler, C.M., Schonbrunn, A. J. Biol. Chem. (1997) [Pubmed]
  18. Kinetics of somatostatin receptor migration in isolated pancreatic islets. Draznin, B., Leitner, J.W., Sussman, K.E. Diabetes (1982) [Pubmed]
  19. NPY neurons express somatostatin receptor subtype 1 in the arcuate nucleus. Fodor, M., van Elk, E.J., Huizinga, C.T., Prins, T., Delemarre-van de Waal, H.A. Neuroreport (2005) [Pubmed]
  20. Persistent lack of somatostatin receptors in gastric mucosa of healing ulcers in rats. Reubi, J.C., Waser, B., Schmassmann, A., Halter, F. Gastroenterology (1994) [Pubmed]
  21. Immunohistochemical and cytochemical localization of the somatostatin receptor subtype sst1 in the somatostatinergic parvocellular neuronal system of the rat hypothalamus. Helboe, L., Stidsen, C.E., Moller, M. J. Neurosci. (1998) [Pubmed]
  22. Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models. Sándor, K., Elekes, K., Szabó, A., Pintér, E., Engström, M., Wurster, S., Szolcsányi, J., Helyes, Z. Eur. J. Pharmacol. (2006) [Pubmed]
  23. Somatostatin in the pontine reticular formation modulates fear potentiation of the acoustic startle response: an anatomical, electrophysiological, and behavioral study. Fendt, M., Koch, M., Schnitzler, H.U. J. Neurosci. (1996) [Pubmed]
  24. Solubilization and characterization of active somatostatin receptors from rat pancreas. Knuhtsen, S., Esteve, J.P., Cambillau, C., Colas, B., Susini, C., Vaysse, N. J. Biol. Chem. (1990) [Pubmed]
  25. Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade. Bito, H., Mori, M., Sakanaka, C., Takano, T., Honda, Z., Gotoh, Y., Nishida, E., Shimizu, T. J. Biol. Chem. (1994) [Pubmed]
  26. Characterization of 17-beta-estradiol-dependent and -independent somatostatin receptor subtypes in rat anterior pituitary. Kimura, N., Hayafuji, C., Kimura, N. J. Biol. Chem. (1989) [Pubmed]
  27. Analogues of somatostatin bind selectively to brain somatostatin receptor subtypes. Raynor, K., Coy, D.C., Reisine, T. J. Neurochem. (1992) [Pubmed]
  28. Distribution of somatostatin receptor subtypes in rat lumbar spinal cord examined with gold-labelled somatostatin and anti-receptor antibodies. Segond von Banchet, G., Schindler, M., Hervieu, G.J., Beckmann, B., Emson, P.C., Heppelmann, B. Brain Res. (1999) [Pubmed]
  29. Involvement of a Pit-1 binding site in the regulation of the rat somatostatin receptor 1 gene expression. Baumeister, H., Meyerhof, W. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  30. Co-purification of a protein tyrosine phosphatase with activated somatostatin receptors from rat pancreatic acinar membranes. Zeggari, M., Esteve, J.P., Rauly, I., Cambillau, C., Mazarguil, H., Dufresne, M., Pradayrol, L., Chayvialle, J.A., Vaysse, N., Susini, C. Biochem. J. (1994) [Pubmed]
  31. Inhibitory role of the somatostatin receptor SST2 on the intracrine-regulated cell proliferation induced by the 210-amino acid fibroblast growth factor-2 isoform: implication of JAK2. Hortala, M., Ferjoux, G., Estival, A., Bertrand, C., Schulz, S., Pradayrol, L., Susini, C., Clemente, F. J. Biol. Chem. (2003) [Pubmed]
  32. Anti-secretory properties of non-peptide somatostatin receptor agonists in isolated rat colon: luminal activity and possible interaction with P-glycoprotein. Emery, P.T., Higgs, N.B., Warhurst, A.C., Carlson, G.L., Warhurst, G. Br. J. Pharmacol. (2002) [Pubmed]
  33. On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogen-activated protein kinase. Sakanaka, C., Ferby, I., Waga, I., Bito, H., Shimizu, T. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  34. Coupling of rat somatostatin receptor subtypes to a G-protein gated inwardly rectifying potassium channel (GIRK1). Kreienkamp, H.J., Hönck, H.H., Richter, D. FEBS Lett. (1997) [Pubmed]
  35. Agonist-mediated endocytosis of rat somatostatin receptor subtype 3 involves beta-arrestin and clathrin coated vesicles. Kreuzer, O.J., Krisch, B., Déry, O., Bunnett, N.W., Meyerhof, W. J. Neuroendocrinol. (2001) [Pubmed]
  36. Characterization of 5'-flanking region of rat somatostatin receptor sst2 gene: transcriptional regulatory elements and activation by Pitx1 and estrogen. Kimura, N., Tomizawa, S., Arai, K.N., Osamura, R.Y., Kimura, N. Endocrinology (2001) [Pubmed]
  37. Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate microarray analysis. Yuferov, V., Kroslak, T., Laforge, K.S., Zhou, Y., Ho, A., Kreek, M.J. Synapse (2003) [Pubmed]
  38. Growth hormone-releasing hormone-synthesizing neurons are a subpopulation of somatostatin receptor-labelled cells in the rat arcuate nucleus: a combined in situ hybridization and receptor light-microscopic radioautographic study. Bertherat, J., Dournaud, P., Bérod, A., Normand, E., Bloch, B., Rostène, W., Kordon, C., Epelbaum, J. Neuroendocrinology (1992) [Pubmed]
  39. Differential regulation of somatostatin receptor types 1-5 in rat aorta after angioplasty. Khare, S., Kumar, U., Sasi, R., Puebla, L., Calderon, L., Lemstrom, K., Hayry, P., Patel, A.Y. FASEB J. (1999) [Pubmed]
  40. Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28. O'Carroll, A.M., Lolait, S.J., König, M., Mahan, L.C. Mol. Pharmacol. (1992) [Pubmed]
  41. Widespread distribution of somatostatin receptor messenger ribonucleic acids in rat pituitary. O'Carroll, A.M., Krempels, K. Endocrinology (1995) [Pubmed]
  42. Increased cell death after therapy with an Arg-Gly-Asp-linked somatostatin analog. Capello, A., Krenning, E.P., Bernard, B.F., Breeman, W.A., van Hagen, M.P., de Jong, M. J. Nucl. Med. (2004) [Pubmed]
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