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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Pdlim3  -  PDZ and LIM domain 3

Rattus norvegicus

Synonyms: Actinin-associated LIM protein, Actn2lp, Alp, Alpha-actinin-2-associated LIM protein, PDZ and LIM domain protein 3, ...
 
 
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High impact information on Pdlim3

  • The respiratory burst was markedly inhibited by blockers of SK2 (apamin) and SK4 channels (clotrimazole and charybdotoxin), and to a lesser extent, by the potent Kv1.3 blocker agitoxin-2 [1].
  • This effect may have involved decreased calcium influx through NMDA receptors and a subsequent reduction in the activation of SK2 calcium-activated potassium channels [2].
  • Alkaline (Alp) and acid (Acp) phosphatase activities were higher in Ga+ than in Ga- calvaria (Ga+: Alp 223 +/- 23.4 U/mg prot, Ga-: Alp 145 +/- 13.3 U/mg prot, P less than 0.02; Ga+: Acp 69.5 +/- 4.7 U/mg prot, Ga-: 57.5 +/- 2.8 U/mg prot, P less than 0.05) [3].
  • Mucosa was scraped, weighed, and analyzed for protein content and Alp activity [4].
  • Samples of mesenteric lymph nodes for standard bacteriological cultures and a fragment of ileum for histological examination and mucosal contents of protein, Alp were obtained [5].
 

Anatomical context of Pdlim3

  • Electrophysiological recordings of SK2 channels in membrane patches from oocytes coexpressing mutant calmodulins revealed that channel gating is mediated by Ca2+ binding to the first and second E-F hand motifs in the N-terminal domain of calmodulin [6].

References

  1. K+ channels and the microglial respiratory burst. Khanna, R., Roy, L., Zhu, X., Schlichter, L.C. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  2. Blockade of NMDA receptors enhances spontaneous sharp waves in rat hippocampal slices. Colgin, L.L., Jia, Y., Sabatier, J.M., Lynch, G. Neurosci. Lett. (2005) [Pubmed]
  3. Bone modeling in gallium nitrate-treated rats. Cournot-Witmer, G., Bourdeau, A., Lieberherr, M., Thil, C.L., Plachot, J.J., Enault, G., Bourdon, R., Balsan, S. Calcif. Tissue Int. (1987) [Pubmed]
  4. Effect of glicentin on gut mucosal growth in rats with jejunal and ileal Thiry-Vella fistulas. Hashimoto, N., Ohyanagi, H., Kazuyuki, S. J. Pediatr. Surg. (2003) [Pubmed]
  5. Effect of acute portal hypertension on gut mucosa. Hashimoto, N., Ohyanagi, H. Hepatogastroenterology (2002) [Pubmed]
  6. Domains responsible for constitutive and Ca(2+)-dependent interactions between calmodulin and small conductance Ca(2+)-activated potassium channels. Keen, J.E., Khawaled, R., Farrens, D.L., Neelands, T., Rivard, A., Bond, C.T., Janowsky, A., Fakler, B., Adelman, J.P., Maylie, J. J. Neurosci. (1999) [Pubmed]
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