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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SLC2A13  -  solute carrier family 2 (facilitated...

Homo sapiens

Synonyms: H(+)-myo-inositol cotransporter, H(+)-myo-inositol symporter, HMIT, Hmit, Proton myo-inositol cotransporter, ...
 
 
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High impact information on SLC2A13

  • Here we describe the identification and functional characterization of a novel H(+)-myo- inositol co-transporter, HMIT, expressed predominantly in the brain [1].
  • Immunofluorescence microscopy analysis showed HMIT expression in glial cells and some neurons [1].
  • Functional expression of HMIT in Xenopus oocytes showed that transport activity was specific for myo-inositol and related stereoisomers with a Michaelis-Menten constant of approximately 100 microM, and that transport activity was strongly stimulated by decreasing pH [1].
  • Much remains to be learned about the transport functions of the recently discovered isoforms (GLUT6-13 and HMIT) and their physiological role in the metabolism of glucose, myo-inositol and perhaps other substrates [2].

References

  1. Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain. Uldry, M., Ibberson, M., Horisberger, J.D., Chatton, J.Y., Riederer, B.M., Thorens, B. EMBO J. (2001) [Pubmed]
  2. The SLC2 family of facilitated hexose and polyol transporters. Uldry, M., Thorens, B. Pflugers Arch. (2004) [Pubmed]
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