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Gene Review

Macf1  -  microtubule-actin crosslinking factor 1

Mus musculus

Synonyms: ABP620, Acf7, Aclp7, Actin cross-linking family 7, MACF, ...
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Disease relevance of Macf1

  • The antiinflammatory effect of A. occidentale stem-bark aqueous extract alone and in combination with grapefruit (Citrus paradisi Macf.) juice was investigated on fresh egg albumin-induced rat paw edema [1].

High impact information on Macf1

  • BPAG1-a is the major isoform in the nervous system and a homologue of the microtubule actin cross-linking factor, MACF [2].
  • At its COOH terminus, mACF7 contains two putative EF-hand calcium-binding motifs and a segment homologous to the growth arrest-specific protein, Gas2 [3].
  • Microtubule actin crosslinking factor 1b: a novel plakin that localizes to the Golgi complex [4].
  • MACF1 (microtubule actin crosslinking factor), also called ACF7 (actin crosslinking family 7) is a cytoskeletal linker protein that can associate with both actin filaments and microtubules [4].
  • We have previously reported the cloning and partial characterization of Acf7, a novel member of the plakin family [5].

Biological context of Macf1

  • To determine whether spontaneous mutants that may be defective in mACF7 exist, we have mapped the mACF7 gene to mouse chromosome 4 [6].

Anatomical context of Macf1

  • Given the implication of several actin binding proteins in genetic disorders, it is important to know the pattern of mACF7 expression. mACF7 transcripts are detected principally in lung, brain, spinal cord, skeletal and cardiac muscle, and skin [6].

Physical interactions of Macf1


Other interactions of Macf1

  • Moreover, mACF7 and Dst display similar isoform diversity and encode similar sized transcripts in the nervous system [6].

Analytical, diagnostic and therapeutic context of Macf1


  1. Potentiation of the antiinflammatory effect of Anacardium occidentale (Linn.) stem-bark aqueous extract by grapefruit juice. Ojewole, J.A. Methods and findings in experimental and clinical pharmacology. (2004) [Pubmed]
  2. The BPAG1 locus: Alternative splicing produces multiple isoforms with distinct cytoskeletal linker domains, including predominant isoforms in neurons and muscles. Leung, C.L., Zheng, M., Prater, S.M., Liem, R.K. J. Cell Biol. (2001) [Pubmed]
  3. Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons. Leung, C.L., Sun, D., Zheng, M., Knowles, D.R., Liem, R.K. J. Cell Biol. (1999) [Pubmed]
  4. Microtubule actin crosslinking factor 1b: a novel plakin that localizes to the Golgi complex. Lin, C.M., Chen, H.J., Leung, C.L., Parry, D.A., Liem, R.K. J. Cell. Sci. (2005) [Pubmed]
  5. Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development. Bernier, G., Pool, M., Kilcup, M., Alfoldi, J., De Repentigny, Y., Kothary, R. Dev. Dyn. (2000) [Pubmed]
  6. Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins. Bernier, G., Mathieu, M., De Repentigny, Y., Vidal, S.M., Kothary, R. Genomics (1996) [Pubmed]
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