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Gene Review

Bik  -  BCL2-interacting killer (apoptosis-inducing)

Rattus norvegicus

Synonyms: Biklk, Blk
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Disease relevance of Bik

  • We have identified a novel cellular protein, Bik, that interacts with the cellular survival-promoting proteins, Bcl-2 and Bcl-xL, as well as the viral survival-promoting proteins, Epstein Barr virus-BHRF1 and adenovirus E1B-19 kDa [1].

High impact information on Bik


Biological context of Bik


Anatomical context of Bik


Associations of Bik with chemical compounds

  • While Bik does not show overt homology to the BH1 and BH2 conserved domains characteristic of the Bcl-2 family, it does share a 9 amino acid domain (BH3) with Bax and Bak which may be a critical determinant for the death-promoting activity of these proteins [1].

Regulatory relationships of Bik

  • This death-promoting activity of Bik can be suppressed by coexpression of Bcl-2, Bcl-XL, EBV-BHRF1 and E1B-19 kDa proteins suggesting that Bik may be a common target for both cellular and viral anti-apoptotic proteins [1].


  1. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Boyd, J.M., Gallo, G.J., Elangovan, B., Houghton, A.B., Malstrom, S., Avery, B.J., Ebb, R.G., Subramanian, T., Chittenden, T., Lutz, R.J. Oncogene (1995) [Pubmed]
  2. Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. Shimizu, S., Tsujimoto, Y. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins. Kasof, G.M., Goyal, L., White, E. Mol. Cell. Biol. (1999) [Pubmed]
  4. Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells. Marshansky, V., Wang, X., Bertrand, R., Luo, H., Duguid, W., Chinnadurai, G., Kanaan, N., Vu, M.D., Wu, J. J. Immunol. (2001) [Pubmed]
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