Gene Review:
Bcl2 - B-cell CLL/lymphoma 2
Rattus norvegicus
Synonyms:
Apoptosis regulator Bcl-2, Bcl-2
- Hypoxia-induced apoptosis in cultured glomerular endothelial cells: involvement of mitochondrial pathways. Tanaka, T., Miyata, T., Inagi, R., Kurokawa, K., Adler, S., Fujita, T., Nangaku, M. Kidney Int. (2003)
- The effect of alpha-melanocyte-stimulating hormone on renal tubular cell apoptosis and tubulointerstitial fibrosis in cyclosporine A nephrotoxicity. Lee, S.Y., Jo, S.K., Cho, W.Y., Kim, H.K., Won, N.H. Transplantation (2004)
- Diabetes enhances apoptosis induced by cerebral ischemia. Li, Z.G., Britton, M., Sima, A.A., Dunbar, J.C. Life Sci. (2004)
- Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphoma. Bobkov, K., Gut, I., Mandys, V., Holý, A., Votruba, I., Otová, B. Anticancer Res. (2001)
- Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells. Huigsloot, M., Tijdens, I.B., Mulder, G.J., van de Water, B. J. Biol. Chem. (2002)
- Loss of anti-apoptotic genes in aging rat crura. Yamanaka, M., Shirai, M., Shiina, H., Shirai, M., Tanaka, Y., Fujime, M., Okuyama, A., Dahiya, R. J. Urol. (2002)
- The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials. Chuang, D.M. Ann. N. Y. Acad. Sci. (2005)
- Bcl-X(L) inhibits apoptosis and necrosis produced by Alzheimer's beta-amyloid1-40 peptide in PC12 cells. Tan, J., Town, T., Placzek, A., Kundtz, A., Yu, H., Mullan, M. Neurosci. Lett. (1999)
- Differential nigral expression of Bcl-2 protein family in chronically haloperidol and clozapine-treated rats: Role in neurotoxicity and stereotyped behavior. Saldaña, M., Bonastre, M., Aguilar, E., Marin, C. Exp. Neurol. (2007)
- Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Newmeyer, D.D., Farschon, D.M., Reed, J.C. Cell (1994)
- Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Shimizu, S., Narita, M., Tsujimoto, Y. Nature (1999)
- Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Rossé, T., Olivier, R., Monney, L., Rager, M., Conus, S., Fellay, I., Jansen, B., Borner, C. Nature (1998)
- Anticancer effect of PMEDAP--monitoring of apoptosis. Bobková, K., Otová, B., Marinov, I., Mandys, V., Panczak, A., Votruba, I., Holý, A. Anticancer Res. (2000)
- Neuroprotective effects of bcl-2 overexpression in hippocampal cultures: interactions with pathways of oxidative damage. Howard, S., Bottino, C., Brooke, S., Cheng, E., Giffard, R.G., Sapolsky, R. J. Neurochem. (2002)
- Activated JNK brings about accelerated apoptosis of Bcl-2-overexpressing C6 glioma cells on treatment with tamoxifen. Moodbidri, M.S., Shirsat, N.V. J. Neurochem. (2005)
- Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia-reperfusion. Toth, A., Jeffers, J.R., Nickson, P., Min, J.Y., Morgan, J.P., Zambetti, G.P., Erhardt, P. Am. J. Physiol. Heart Circ. Physiol. (2006)
- Bcl-2/Bax protein expression in heart, slow-twitch and fast-twitch muscles in young rats growing under chronic hypoxia conditions. Riva, C., Chevrier, C., Pasqual, N., Saks, V., Rossi, A. Mol. Cell. Biochem. (2001)
- Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons. Prehn, J.H., Bindokas, V.P., Marcuccilli, C.J., Krajewski, S., Reed, J.C., Miller, R.J. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Activation of pro-apoptotic cascade by dopamine in renal epithelial cells is fully dependent on hydrogen peroxide generation by monoamine oxidases. Bianchi, P., Séguélas, M.H., Parini, A., Cambon, C. J. Am. Soc. Nephrol. (2003)
- Suppression of cell proliferation, induction of apoptosis and cell cycle arrest: Chemopreventive activity of vanadium in vivo and in vitro. Ray, R.S., Ghosh, B., Rana, A., Chatterjee, M. Int. J. Cancer (2007)
- Regression of the decidualized mesometrium and decidual cell apoptosis are associated with a shift in expression of Bcl2 family members. Dai, D., Moulton, B.C., Ogle, T.F. Biol. Reprod. (2000)
- Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. Leri, A., Claudio, P.P., Li, Q., Wang, X., Reiss, K., Wang, S., Malhotra, A., Kajstura, J., Anversa, P. J. Clin. Invest. (1998)
- Bcl-2 changes conformation to inhibit Bax oligomerization. Dlugosz, P.J., Billen, L.P., Annis, M.G., Zhu, W., Zhang, Z., Lin, J., Leber, B., Andrews, D.W. EMBO J. (2006)
- Altered expression of Bcl2, Bad and Bax mRNA occurs in the rat cerebellum within hours after ethanol exposure on postnatal day 4 but not on postnatal day 9. Ge, Y., Belcher, S.M., Pierce, D.R., Light, K.E. Brain Res. Mol. Brain Res. (2004)
- Palmitate induced lipoapoptosis of exocrine pancreas AR42J cells. Landau, Z., Forti, E., Alcaly, M., Birk, R.Z. Apoptosis (2006)
- Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry. Janumyan, Y.M., Sansam, C.G., Chattopadhyay, A., Cheng, N., Soucie, E.L., Penn, L.Z., Andrews, D., Knudson, C.M., Yang, E. EMBO J. (2003)
- Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons. Linseman, D.A., Phelps, R.A., Bouchard, R.J., Le, S.S., Laessig, T.A., McClure, M.L., Heidenreich, K.A. J. Neurosci. (2002)
- ERK2 prohibits apoptosis-induced subcellular translocation of orphan nuclear receptor NGFI-B/TR3. Jacobs, C.M., Boldingh, K.A., Slagsvold, H.H., Thoresen, G.H., Paulsen, R.E. J. Biol. Chem. (2004)
- Gas1 is induced during and participates in excitotoxic neuronal death. Mellström, B., Ceña, V., Lamas, M., Perales, C., Gonzalez, C., Naranjo, J.R. Mol. Cell. Neurosci. (2002)
- Overexpression of bcl-2 results in reduction of cytochrome c content and inhibition of complex I activity. Schwarz, C.S., Evert, B.O., Seyfried, J., Schaupp, M., Kunz, W.S., Vielhaber, S., Klockgether, T., Wüllner, U. Biochem. Biophys. Res. Commun. (2001)
- Activated Ha-ras induces apoptosis by association with phosphorylated Bcl-2 in a mitogen-activated protein kinase-independent manner. Navarro, P., Valverde, A.M., Benito, M., Lorenzo, M. J. Biol. Chem. (1999)
- Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: a possible cause for erectile dysfunction in diabetes. Jesmin, S., Sakuma, I., Salah-Eldin, A., Nonomura, K., Hattori, Y., Kitabatake, A. J. Mol. Endocrinol. (2003)
- Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Wagner, A.J., Small, M.B., Hay, N. Mol. Cell. Biol. (1993)
- Bcl-2 blocks cisplatin-induced apoptosis by suppression of ERK-mediated p53 accumulation in B104 cells. Park, S.A., Park, H.J., Lee, B.I., Ahn, Y.H., Kim, S.U., Choi, K.S. Brain Res. Mol. Brain Res. (2001)
- Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. Horiuchi, M., Hayashida, W., Kambe, T., Yamada, T., Dzau, V.J. J. Biol. Chem. (1997)
- Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. Pugazhenthi, S., Nesterova, A., Sable, C., Heidenreich, K.A., Boxer, L.M., Heasley, L.E., Reusch, J.E. J. Biol. Chem. (2000)
- Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu, S.Y., Kaipia, A., McGee, E., Lomeli, M., Hsueh, A.J. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells. Kim, B.C., Mamura, M., Choi, K.S., Calabretta, B., Kim, S.J. Mol. Cell. Biol. (2002)
- Implication of Bcl-2 family genes in basal and D-amphetamine-induced apoptosis in preneoplastic and neoplastic rat liver lesions. De Miglio, M.R., Muroni, M.R., Simile, M.M., Calvisi, D.F., Tolu, P., Deiana, L., Carru, A., Bonelli, G., Feo, F., Pascale, R.M. Hepatology (2000)
- Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity. Zhao, H., Yenari, M.A., Cheng, D., Sapolsky, R.M., Steinberg, G.K. J. Neurochem. (2003)