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Gene Review

Slc26a3  -  solute carrier family 26 (anion exchanger)...

Rattus norvegicus

Synonyms: Chloride anion exchanger, Down-regulated in adenoma, Dra, Protein DRA, Solute carrier family 26 member 3
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Disease relevance of Slc26a3

  • The recently discovered dra (down-regulated in adenoma) gene encodes a transport protein (DRA) for SO4(2-), Cl-, and HCO3-. The aim of this study was to investigate whether DRA may be the duodenal apical Cl-/HCO3- exchanger [1].
  • We hypothesize that gestational mortality caused by Dr/Afa+ E. coli is mediated by one of these two proteins, Dra/AfaE or Dra/AfaD [2].

High impact information on Slc26a3

  • METHODS: DRA, Na+/H+ exchanger (NHE) isoform 3, and anion exchanger isoform (AE) 2 messenger RNA expression levels were studied in rat, rabbit, and human gastrointestinal tract by semiquantitative reverse-transcription polymerase chain reaction and in situ hybridization (DRA in human intestine) [1].
  • Two components of the adhesin, Dra/AfaE and Dra/AfaD, considered virulence factors, are responsible for bacterial binding and internalization [2].
  • This indicates that AE1 encodes surface cell-specific aldosterone-regulated Cl/HCO(3) exchange, whereas DRA encodes aldosterone-insensitive Cl/OH exchange [3].
  • In contrast, AE2 polypeptide is expressed in basolateral membranes and DRA protein is expressed in apical membranes of both surface and crypt cells [3].

Analytical, diagnostic and therapeutic context of Slc26a3


  1. Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum. Jacob, P., Rossmann, H., Lamprecht, G., Kretz, A., Neff, C., Lin-Wu, E., Gregor, M., Groneberg, D.A., Kere, J., Seidler, U. Gastroenterology (2002) [Pubmed]
  2. Dra/AfaE adhesin of uropathogenic Dr/Afa+ Escherichia coli mediates mortality in pregnant rats. Wroblewska-Seniuk, K., Selvarangan, R., Hart, A., Pladzyk, R., Goluszko, P., Jafari, A., du Merle, L., Nowicki, S., Yallampalli, C., Le Bouguénec, C., Nowicki, B. Infect. Immun. (2005) [Pubmed]
  3. Regulation of DRA and AE1 in rat colon by dietary Na depletion. Rajendran, V.M., Black, J., Ardito, T.A., Sangan, P., Alper, S.L., Schweinfest, C., Kashgarian, M., Binder, H.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
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