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Gene Review

Slc26a3  -  solute carrier family 26, member 3

Mus musculus

Synonyms: 9030623B18Rik, 9130013M11Rik, AV376035, Chloride anion exchanger, Down-regulated in adenoma, ...
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Disease relevance of Slc26a3

  • Mutations in the SLC26A3 (DRA (down-regulated in adenoma)) gene constitute the molecular etiology of congenital chloride-losing diarrhea in humans [1].

High impact information on Slc26a3

  • The plasma membrane expression of major apical anion exchanger DRA (SLC26A3) was considerably reduced in EPEC-infected cells, corresponding with decreased Cl(-)/OH(-) exchange activity [2].
  • Our data demonstrate that EspG and EspG2 play an important role in contributing to EPEC infection-associated inhibition of luminal membrane chloride transport via modulation of surface DRA expression [2].
  • The Dra mutation has previously been shown to abrogate phosphorylation as well as T-Ag binding [3].
  • Using an RNase protection assay, we found that dra mRNA expression is limited to the small intestine and colon in mouse, therefore identifying Dra as an intestine-specific sulfate transporter. dra also had a unique pattern of expression during intestinal development [4].
  • This functional characterization provides the foundation for investigation of the role of Dra in intestinal sulfate transport and in the malignant phenotype [4].

Biological context of Slc26a3

  • In conclusion, these results point to the role of Slc26a6 in HCO(3)(-) efflux at the apical membrane and also suggest the presence of a robust Slc26a3 compensatory upregulation, which can replace the function of Slc26a6 in pancreatic ducts [5].
  • The down-regulated in adenoma (Dra) gene encoding intestine-specific anion transporter maps to mouse chromosome 12 [6].
  • We have established a strain of transgenic mice in which the HLA-DRA gene was integrated into the X-chromosome and the xenogeneic mixed isotype molecule, DR alpha E beta b, was expressed in a cell type-specific manner, although the transgenic DRA gene contained only 268 base pairs of the 5'-flanking region [7].
  • SSCP analysis of Dra I-digested PCR product of 393 bp also showed different patterns in FD2 and FD7 samples [8].

Associations of Slc26a3 with chemical compounds

  • To investigate the evolutionary dynamics at Mhc class II DR genes of mice (genus Mus), we sequenced the peptide binding regions (PBRs) of 41 DRB (= E beta) genes and eight DRA (= E alpha) genes from 15 strains representing eight species [9].
  • Tca and Esa are assigned provisionally to the first short-consensus repeat (SCR), UMC to the second SCR, Dra to the third SCR and Cra, WESa and WESb to the fourth SCR or to the serine/threonine rich region of the DAF protein [10].

Regulatory relationships of Slc26a3

  • The mRNA expression of Slc26a3 (downregulated in adenoma) and Slc26a6 (putative anion exchanger-1) was similar between WT and CF duodena [11].

Analytical, diagnostic and therapeutic context of Slc26a3

  • Fluorescence-activated cell sorting (FACS) analysis revealed that cultures induced to overexpress either wild-type or Dra mutant Rb proteins were significantly enriched for cells with a G2 DNA content [3].
  • PCR of merozoite DNA using primer pairs JNB33/JNB54 and restriction enzyme digestion of the 1100 bp product with Dra I indicated the organism was S. neurona [12].


  1. slc26a3 (dra)-deficient Mice Display Chloride-losing Diarrhea, Enhanced Colonic Proliferation, and Distinct Up-regulation of Ion Transporters in the Colon. Schweinfest, C.W., Spyropoulos, D.D., Henderson, K.W., Kim, J.H., Chapman, J.M., Barone, S., Worrell, R.T., Wang, Z., Soleimani, M. J. Biol. Chem. (2006) [Pubmed]
  2. Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli. Gill, R.K., Borthakur, A., Hodges, K., Turner, J.R., Clayburgh, D.R., Saksena, S., Zaheer, A., Ramaswamy, K., Hecht, G., Dudeja, P.K. J. Clin. Invest. (2007) [Pubmed]
  3. Overproduction of Rb protein after the G1/S boundary causes G2 arrest. Karantza, V., Maroo, A., Fay, D., Sedivy, J.M. Mol. Cell. Biol. (1993) [Pubmed]
  4. The Down regulated in Adenoma (dra) gene encodes an intestine-specific membrane sulfate transport protein. Silberg, D.G., Wang, W., Moseley, R.H., Traber, P.G. J. Biol. Chem. (1995) [Pubmed]
  5. Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct. Ishiguro, H., Namkung, W., Yamamoto, A., Wang, Z., Worrell, R.T., Xu, J., Lee, M.G., Soleimani, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2007) [Pubmed]
  6. The down-regulated in adenoma (Dra) gene encoding intestine-specific anion transporter maps to mouse chromosome 12. Kunieda, T., Takahashi, K., Shinkai, Y., Tsuji, T., Schweinfest, C.W., Katoh, H. Exp. Anim. (2000) [Pubmed]
  7. T-cell repertoire in a strain of transgenic C57BL/6 mice with the HLA-DRA gene on the X-chromosome. Fukui, Y., Esaki, Y., Kimura, A., Hirokawa, K., Nishimura, Y., Sasazuki, T. Immunogenetics (1993) [Pubmed]
  8. Detection of MHV-RNAs in mouse intestines and in filter dust in mouse room ventilation duct by a modified RT-nested PCR. Oyanagi, M., Kato, A., Yamada, Y.K., Sato, N.L. Exp. Anim. (2004) [Pubmed]
  9. Ancestral polymorphism of Mhc class II genes in mice: implications for balancing selection and the mammalian molecular clock. Edwards, S.V., Chesnut, K., Satta, Y., Wakeland, E.K. Genetics (1997) [Pubmed]
  10. Use of the MAIEA technique to confirm the relationship between the Cromer antigens and decay-accelerating factor and to assign provisionally antigens to the short-consensus repeats. Petty, A.C., Daniels, G.L., Anstee, D.J., Tippett, P. Vox Sang. (1993) [Pubmed]
  11. Chloride conductance of CFTR facilitates basal Cl-/HCO3- exchange in the villous epithelium of intact murine duodenum. Simpson, J.E., Gawenis, L.R., Walker, N.M., Boyle, K.T., Clarke, L.L. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  12. Biological characterisation of Sarcocystis neurona isolated from a Southern sea otter (Enhydra lutris nereis). Lindsay, D.S., Thomas, N.J., Dubey, J.P. Int. J. Parasitol. (2000) [Pubmed]
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