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Gene Review:

Selm - selenoprotein M

Mus musculus

Synonyms: 1500040L08Rik, A230103K18, SelM, Selenoprotein M, Sepm

Hwang, D.Y. et al., Korotkov, K.V. et al., Ferguson, A.D. et al., Labunskyy, V.M. et al.

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Psychiatry related information on Selm

Differentially expressed genes in transgenic mice carrying human mutant presenilin-2 (N141I): correlation of selenoprotein M with Alzheimer's disease [1].

High impact information on Selm

The 3-kb human SelM-encoding gene has five exons and is located on chromosome 22 but has not been correctly identified by either Celera or the public Human Genome Project. We characterized human and mouse SelM cDNA sequences and expressed the selenoprotein in various mammalian cell lines [2].
A physiological role for Sep15 and SelM as thiol-disulfide oxidoreductases and their contribution to the quality control pathways of the endoplasmic reticulum are discussed [3].
Sequence analysis of members of the Sep15 family identified a novel N-terminal cysteine-rich domain in Sep15 that is absent in SelM [4].
Initially, a cloning corresponding to human selenoprotein M (hSelM) was chosen for investigation further because SelM induced by sodium selenite, a pro-oxidant, may have a functional role in catalyze the free radicals [1].

References

Differentially expressed genes in transgenic mice carrying human mutant presenilin-2 (N141I): correlation of selenoprotein M with Alzheimer's disease. Hwang, D.Y., Cho, J.S., Oh, J.H., Shim, S.B., Jee, S.W., Lee, S.H., Seo, S.J., Lee, S.K., Lee, S.H., Kim, Y.K. Neurochem. Res. (2005) [Pubmed]
Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. Korotkov, K.V., Novoselov, S.V., Hatfield, D.L., Gladyshev, V.N. Mol. Cell. Biol. (2002) [Pubmed]
NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. Ferguson, A.D., Labunskyy, V.M., Fomenko, D.E., Araç, D., Chelliah, Y., Amezcua, C.A., Rizo, J., Gladyshev, V.N., Deisenhofer, J. J. Biol. Chem. (2006) [Pubmed]
A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase. Labunskyy, V.M., Ferguson, A.D., Fomenko, D.E., Chelliah, Y., Hatfield, D.L., Gladyshev, V.N. J. Biol. Chem. (2005) [Pubmed]

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SELM	Bos taurus
SELM	Canis lupus familiaris
selm	Danio rerio
SELM	Gallus gallus
SELM	Homo sapiens
SELM	Macaca mulatta
SELM	Pan troglodytes
Selm	Rattus norvegicus
selm	Xenopus (Silurana) tropicalis

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