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Gene Review

SLITRK1  -  SLIT and NTRK-like family, member 1

Homo sapiens

Synonyms: KIAA1910, LRRC12, Leucine-rich repeat-containing protein 12, SLIT and NTRK-like protein 1, TTM, ...
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Disease relevance of SLITRK1


Psychiatry related information on SLITRK1


High impact information on SLITRK1


Biological context of SLITRK1

  • Locating genetic loci by associating the phenotype with DNA translocations, inversions, gain or losses, State et al. identified SLITRK1 as a candidate gene in an individual with GTS and inv(13) (q31.1; q33.1) [6].


  1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. Aruga, J., Yokota, N., Mikoshiba, K. Gene (2003) [Pubmed]
  2. A novel family of slitrk genes is expressed on hematopoietic stem cells and leukemias. Milde, T., Shmelkov, S.V., Jensen, K.K., Zlotchenko, G., Petit, I., Rafii, S. Leukemia (2007) [Pubmed]
  3. SLITRK1 trouble in Tourette's syndrome. Burton, A. Lancet neurology. (2005) [Pubmed]
  4. SLITRK1 mutations in trichotillomania. Zuchner, S., Cuccaro, M.L., Tran-Viet, K.N., Cope, H., Krishnan, R.R., Pericak-Vance, M.A., Wright, H.H., Ashley-Koch, A. Mol. Psychiatry (2006) [Pubmed]
  5. Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorder. Wendland, J.R., Kruse, M.R., Murphy, D.L. Mol. Psychiatry (2006) [Pubmed]
  6. A new gene for Tourette's syndrome: a window into causal mechanisms? Grados, M.A., Walkup, J.T. Trends Genet. (2006) [Pubmed]
  7. Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses. Keen-Kim, D., Mathews, C.A., Reus, V.I., Lowe, T.L., Herrera, L.D., Budman, C.L., Gross-Tsur, V., Pulver, A.E., Bruun, R.D., Erenberg, G., Naarden, A., Sabatti, C., Freimer, N.B. Hum. Mol. Genet. (2006) [Pubmed]
  8. Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome. Deng, H., Le, W.D., Xie, W.J., Jankovic, J. Acta Neurol. Scand. (2006) [Pubmed]
  9. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Abelson, J.F., Kwan, K.Y., O'Roak, B.J., Baek, D.Y., Stillman, A.A., Morgan, T.M., Mathews, C.A., Pauls, D.L., Rasin, M.R., Gunel, M., Davis, N.R., Ercan-Sencicek, A.G., Guez, D.H., Spertus, J.A., Leckman, J.F., Dure, L.S., Kurlan, R., Singer, H.S., Gilbert, D.L., Farhi, A., Louvi, A., Lifton, R.P., Sestan, N., State, M.W. Science (2005) [Pubmed]
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