Disease relevance of Trichotillomania

• Using a knowledge of normal hair patterns and histologic features, the physician can identify common baldness, trichotillomania, alopecia areata, discoid lupus erythematosus, lichen planopilaris, tinea capitis and follicular mucinosis [1].
• In addition, pimozide has been found to be efficacious in the treatment of body dysmorphic disorder, metastatic melanoma, trichotillomania, and trigeminal and postherpetic neuralgia [2].

Psychiatry related information on Trichotillomania

• Response of obsessive-compulsive disorder and trichotillomania to serotonin reuptake blockers [3].
• Treatment of generalized anxiety disorder and trichotillomania with buspirone [4].
• RESULTS: A series of patients with OCD (N = 8), trichotillomania (N = 5), and Tourette's syndrome (N = 3) who were refractory to treatment with serotonin reuptake inhibitors had received risperidone augmentation [5].
• METHOD: Six patients with either obsessive compulsive disorder, trichotillomania, anxiety, or affective disorders who suffered sexual side effects after treatment with serotonin reuptake blockers were given yohimbine on a p.r.n. basis in an open clinical trial [6].
• An individual with pedophilia and trichotillomania was treated with sertraline [7].

High impact information on Trichotillomania

• The aberrant behavior observed in Hoxb8 mutants is not unlike that of humans suffering from the OC-spectrum disorder, trichotillomania [8].
• CONCLUSIONS: Behavioral therapy is highly effective for reducing symptoms of trichotillomania in the short term, whereas fluoxetine is not [9].
• BACKGROUND: Both behavioral therapy (BT) and serotonin reuptake inhibitors have been reported effective in the treatment of trichotillomania [9].
• Regional cerebral glucose metabolism of women with trichotillomania [10].
• Treatment of resistant trichotillomania with paroxetine [11].

Chemical compound and disease context of Trichotillomania

• Trichotillomania treated with clomipramine and a topical steroid [12].
• Serotonergic responsivity in trichotillomania: neuroendrocrine effects of m-chlorophenylpiperazine [13].
• Further controlled trials of pimozide augmentation in trichotillomania are needed [14].
• Fluvoxamine treatment of trichotillomania [15].
• MAO inhibitor therapy in trichotillomania associated with depression: case report [16].

Gene context of Trichotillomania

• RESULTS: Trichotillomania, hypertrophic cardiomyopathy, and idiopathic hyperCKemia, in 1 patient each, preceded the development of the full clinical spectrum of CHAC by 2 to 20 years [17].
• Trichotillomania and carpal tunnel syndrome [18].
• Such a case of trichotillomania occurring with major depressive disorder is reported in this paper [19].
• (J Am Acad Dermatol 2002;46:807-21.) Learning objective: At the conclusion of this learning activity, participants should be familiar with clinical and histologic aspects of trichotillomania and should be able to cope with the risks of medical and psychiatric complications in these patients [20].
• Mean+/-S.D. CSF IL-6 levels did not differ between OCD patients (n=26) (2.4+/-1.1 pg/ml) and controls (n=26) (2.4+/-1.9 pg/ml) or between trichotillomania patients (n=9) (2.3+/-0.8 pg/ml) and their matched controls (n=14) (1.9+/-0.5 pg/ml) [21].

Analytical, diagnostic and therapeutic context of Trichotillomania

• Positron emission tomography and 18-F-fluorodeoxyglucose were used to study resting cerebral glucose metabolism in 10 adult women with trichotillomania and 20 age-matched female controls [10].
• A placebo-controlled, double-blind crossover study of fluoxetine in trichotillomania [22].
• Alternative pharmacotherapy for trichotillomania: a report of successful bupropion use [23].
• To explore a possible relationship between trichotillomania, (TTM) (compulsive hair pulling) and Obsessive Compulsive Disorder (OCD), 65 out of 69 (94%) first degree relatives of 16 female probands with severe chronic TTM were compared with two control groups for OCD and for TTM [24].

References