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Gene Review

Wnt7a  -  wingless-type MMTV integration site family...

Rattus norvegicus

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High impact information on Wnt7a

  • Only the conditioned medium collected from cultures transfected with ApoE4 induced a significant inhibition of Wnt7a-stimulated gene expression, confirming that ApoE4 has an extracellular action that is not shared by the other ApoE isoforms [1].
  • The remarkable downregulation of Wnt7a mRNA in response to EE was considered to be important to understand the various uterine phenomena affected by ER agonists [2].
  • Although the time courses of Wnt4, Wnt5a, and Wnt7a mRNA status varied until 12 h after EE administration, all of them were simultaneously downregulated at 24 and 48 h [2].
  • Comparative genomics on Wnt7a orthologs [3].
  • Here, we identified and characterized the rat Wnt7a gene using bioinformatics [3].

Biological context of Wnt7a

  • The rat Wnt7a gene, consisting of four exons, was located within the AC106100.7 genome sequence [3].
  • Rat Wnt7a (349 aa) with 24 Cys residues and 3 Asn-linked glycosylation sites showed 99.7, 99.1 and 93.7% total-amino- acid identity with mouse Wnt7a, human WNT7A and chicken wnt7a, respectively [3].


  1. Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells. Caruso, A., Motolese, M., Iacovelli, L., Caraci, F., Copani, A., Nicoletti, F., Terstappen, G.C., Gaviraghi, G., Caricasole, A. J. Neurochem. (2006) [Pubmed]
  2. Differential expression patterns of Wnt and beta-catenin/TCF target genes in the uterus of immature female rats exposed to 17alpha-ethynyl estradiol. Katayama, S., Ashizawa, K., Fukuhara, T., Hiroyasu, M., Tsuzuki, Y., Tatemoto, H., Nakada, T., Nagai, K. Toxicol. Sci. (2006) [Pubmed]
  3. Comparative genomics on Wnt7a orthologs. Katoh, M., Katoh, M. Oncol. Rep. (2005) [Pubmed]
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