High impact information on Wnt7a

• Only the conditioned medium collected from cultures transfected with ApoE4 induced a significant inhibition of Wnt7a-stimulated gene expression, confirming that ApoE4 has an extracellular action that is not shared by the other ApoE isoforms [1].
• The remarkable downregulation of Wnt7a mRNA in response to EE was considered to be important to understand the various uterine phenomena affected by ER agonists [2].
• Although the time courses of Wnt4, Wnt5a, and Wnt7a mRNA status varied until 12 h after EE administration, all of them were simultaneously downregulated at 24 and 48 h [2].
• Comparative genomics on Wnt7a orthologs [3].
• Here, we identified and characterized the rat Wnt7a gene using bioinformatics [3].

Biological context of Wnt7a

• The rat Wnt7a gene, consisting of four exons, was located within the AC106100.7 genome sequence [3].
• Rat Wnt7a (349 aa) with 24 Cys residues and 3 Asn-linked glycosylation sites showed 99.7, 99.1 and 93.7% total-amino- acid identity with mouse Wnt7a, human WNT7A and chicken wnt7a, respectively [3].

References