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Gene Review

Wnt5a  -  wingless-type MMTV integration site family...

Rattus norvegicus

Synonyms: Protein Wnt-5a, Wnt-5a
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Disease relevance of Wnt5a


High impact information on Wnt5a

  • 5) E2 activated the expression of the Wnt-5a and Wnt-7a ligands, and at the same time, E2, through the alpha-estrogen receptor, was able to prevent the excitotoxic A beta-induced rise in bulk-free Ca2+ as an alternative pathway to increase cell viability [2].
  • Ablation of Wnt5a by antisense cDNA inhibited LIF-induced cell adhesion [3].
  • Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes [3].
  • Wnt-5a expression in the rat neuronal progenitor cell line ST14A [1].
  • Wnt5a and Wnt6 expression was higher in PC12/Wnt1 cells than in PC12 or PC12/flat [4].

Biological context of Wnt5a


  1. Wnt-5a expression in the rat neuronal progenitor cell line ST14A. Peters, S., Mix, E., Bauer, P., Weinelt, S., Schubert, B., Knoblich, R., Böttcher, T., Strauss, U., Pahnke, J., Cattaneo, E., Wree, A., Rolfs, A. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2004) [Pubmed]
  2. Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway. Quintanilla, R.A., Muñoz, F.J., Metcalfe, M.J., Hitschfeld, M., Olivares, G., Godoy, J.A., Inestrosa, N.C. J. Biol. Chem. (2005) [Pubmed]
  3. Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes. Fujio, Y., Matsuda, T., Oshima, Y., Maeda, M., Mohri, T., Ito, T., Takatani, T., Hirata, M., Nakaoka, Y., Kimura, R., Kishimoto, T., Azuma, J. FEBS Lett. (2004) [Pubmed]
  4. Differential expression of Wnt genes in normal and flat variants of PC12 cells, a cell line responsive to ectopic Wnt1 expression. Erdreich-Epstein, A., Shackleford, G.M. Growth Factors (1998) [Pubmed]
  5. Comparative genomics on Wnt5a and Wnt5b genes. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
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