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Gene Review:

IL22RA2 - interleukin 22 receptor, alpha 2

Homo sapiens

Synonyms: CRF2-10, CRF2-S1, CRF2X, Cytokine receptor class-II member 10, Cytokine receptor family 2 member 10, ...

Whittington, H.A. et al., Nagalakshmi, M.L. et al., Kotenko, S.V. et al., Weber, G.F. et al., Nagalakshmi, M.L. et al.

Kotenko, Izotova, Mirochnitchenko, Esterova, Dickensheets, Donnelly, Pestka,

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Disease relevance of IL22RA2

To further analyze the role of IL-22 during septic peritonitis, mice were treated with recombinant IL-22BP generated as Fcgamma2a fusion protein [1].
We hypothesize that IL-22 and IL-22BP are involved in inflammatory regulation and its subsequent role in the pathogenesis of inflammatory lung disease [2].

High impact information on IL22RA2

Thus, the soluble receptor designated IL-22BP inhibits IL-22 activity by binding IL-22 and blocking its interaction with the cell surface IL-22R complex [3].
Binding can be blocked by the soluble receptor, IL-22 binding protein (IL-22BP) [2].
IL-22BP mRNA is expressed in AM, AE cells, and neutrophils [2].
Interestingly, IL-22BP was quite specifically expressed by dendritic cells [4].

Biological context of IL22RA2

IL-22-mediated effects on the Colo205 cells were also inhibited in the presence of IL-22 binding protein (IL-22BP), a soluble receptor with structural similarity to IL-22R1 [5].

References

Inhibition of Interleukin-22 Attenuates Bacterial Load and Organ Failure during Acute Polymicrobial Sepsis. Weber, G.F., Schlautkötter, S., Kaiser-Moore, S., Altmayr, F., Holzmann, B., Weighardt, H. Infect. Immun. (2007) [Pubmed]
Interleukin-22: a potential immunomodulatory molecule in the lung. Whittington, H.A., Armstrong, L., Uppington, K.M., Millar, A.B. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. Kotenko, S.V., Izotova, L.S., Mirochnitchenko, O.V., Esterova, E., Dickensheets, H., Donnelly, R.P., Pestka, S. J. Immunol. (2001) [Pubmed]
Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization. Nagalakshmi, M.L., Murphy, E., McClanahan, T., de Waal Malefyt, R. Int. Immunopharmacol. (2004) [Pubmed]
Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells. Nagalakshmi, M.L., Rascle, A., Zurawski, S., Menon, S., de Waal Malefyt, R. Int. Immunopharmacol. (2004) [Pubmed]

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