Gene Review:
IL22 - interleukin 22
Homo sapiens
Synonyms:
Cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor, IL-21, IL-22, IL-D110, ...
Weighardt,
Blechert,
Holzmann,
Akdis,
Mani,
Olszak,
Yilmaz,
Auernhammer,
Izotova,
Pestka,
Diepolder,
Blaser,
Otte,
Jagla,
Esterova,
Oral,
Donnelly,
Kotenko,
Janssen,
Zitzmann,
Marquardt,
Göke,
Izotova,
Dickensheets,
Essler,
Donnelly,
Dambacher,
Kotenko,
Pestka,
Kotenko,
Herrmann,
Esterova,
Mirochnitchenko,
Brand,
Weber,
Mirochnitchenko,
Beigel,
Seiderer,
Zumkehr,
Eichhorst,
Dickensheets,
Gaertner,
Popp,
Leclair,
Erl,
Akdis,
Ochsenkühn,
- Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Andoh, A., Zhang, Z., Inatomi, O., Fujino, S., Deguchi, Y., Araki, Y., Tsujikawa, T., Kitoh, K., Kim-Mitsuyama, S., Takayanagi, A., Shimizu, N., Fujiyama, Y. Gastroenterology (2005)
- Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Dumoutier, L., Van Roost, E., Colau, D., Renauld, J.C. Proc. Natl. Acad. Sci. U.S.A. (2000)
- IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26. Conti, P., Kempuraj, D., Frydas, S., Kandere, K., Boucher, W., Letourneau, R., Madhappan, B., Sagimoto, K., Christodoulou, S., Theoharides, T.C. Immunol. Lett. (2003)
- Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2. Li, J., Tomkinson, K.N., Tan, X.Y., Wu, P., Yan, G., Spaulding, V., Deng, B., Annis-Freeman, B., Heveron, K., Zollner, R., De Zutter, G., Wright, J.F., Crawford, T.K., Liu, W., Jacobs, K.A., Wolfman, N.M., Ling, V., Pittman, D.D., Veldman, G.M., Fouser, L.A. Int. Immunopharmacol. (2004)
- Antiapoptotic activity of autocrine interleukin-22 and therapeutic effects of interleukin-22-small interfering RNA on human lung cancer xenografts. Zhang, W., Chen, Y., Wei, H., Zheng, C., Sun, R., Zhang, J., Tian, Z. Clin. Cancer Res. (2008)
- A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. Caruso, R., Fina, D., Peluso, I., Stolfi, C., Fantini, M.C., Gioia, V., Caprioli, F., Del Vecchio Blanco, G., Paoluzi, O.A., Macdonald, T.T., Pallone, F., Monteleone, G. Gastroenterology (2007)
- A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Xu, W., Presnell, S.R., Parrish-Novak, J., Kindsvogel, W., Jaspers, S., Chen, Z., Dillon, S.R., Gao, Z., Gilbert, T., Madden, K., Schlutsmeyer, S., Yao, L., Whitmore, T.E., Chandrasekher, Y., Grant, F.J., Maurer, M., Jelinek, L., Storey, H., Brender, T., Hammond, A., Topouzis, S., Clegg, C.H., Foster, D.C. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Inhibition of Interleukin-22 Attenuates Bacterial Load and Organ Failure during Acute Polymicrobial Sepsis. Weber, G.F., Schlautkötter, S., Kaiser-Moore, S., Altmayr, F., Holzmann, B., Weighardt, H. Infect. Immun. (2007)
- IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Brand, S., Beigel, F., Olszak, T., Zitzmann, K., Eichhorst, S.T., Otte, J.M., Diepolder, H., Marquardt, A., Jagla, W., Popp, A., Leclair, S., Herrmann, K., Seiderer, J., Ochsenkühn, T., Göke, B., Auernhammer, C.J., Dambacher, J. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. Kotenko, S.V., Izotova, L.S., Mirochnitchenko, O.V., Esterova, E., Dickensheets, H., Donnelly, R.P., Pestka, S. J. Biol. Chem. (2001)
- Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells. Nagalakshmi, M.L., Rascle, A., Zurawski, S., Menon, S., de Waal Malefyt, R. Int. Immunopharmacol. (2004)
- Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region. Koch, O., Rockett, K., Jallow, M., Pinder, M., Sisay-Joof, F., Kwiatkowski, D. Genes Immun. (2005)
- Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Radaeva, S., Sun, R., Pan, H.N., Hong, F., Gao, B. Hepatology (2004)
- Cutting edge: immune cells as sources and targets of the IL-10 family members? Wolk, K., Kunz, S., Asadullah, K., Sabat, R. J. Immunol. (2002)
- IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. Boniface, K., Bernard, F.X., Garcia, M., Gurney, A.L., Lecron, J.C., Morel, F. J. Immunol. (2005)
- Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. Lejeune, D., Dumoutier, L., Constantinescu, S., Kruijer, W., Schuringa, J.J., Renauld, J.C. J. Biol. Chem. (2002)
- IL-22-Mediated Tumor Growth Reduction Correlates with Inhibition of ERK1/2 and AKT Phosphorylation and Induction of Cell Cycle Arrest in the G2-M Phase. Weber, G.F., Gaertner, F.C., Erl, W., Janssen, K.P., Blechert, B., Holzmann, B., Weighardt, H., Essler, M. J. Immunol. (2006)
- Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. Kotenko, S.V., Izotova, L.S., Mirochnitchenko, O.V., Esterova, E., Dickensheets, H., Donnelly, R.P., Pestka, S. J. Immunol. (2001)
- Crystal structure of recombinant human interleukin-22. Nagem, R.A., Colau, D., Dumoutier, L., Renauld, J.C., Ogata, C., Polikarpov, I. Structure (Camb.) (2002)
- Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26. Oral, H.B., Kotenko, S.V., Yilmaz, M., Mani, O., Zumkehr, J., Blaser, K., Akdis, C.A., Akdis, M. Eur. J. Immunol. (2006)
- Induction of interleukin-19 and interleukin-22 after cardiac surgery with cardiopulmonary bypass. Hsing, C.H., Hsieh, M.Y., Chen, W.Y., Cheung So, E., Cheng, B.C., Chang, M.S. Ann. Thorac. Surg. (2006)
- Interleukin-22: a potential immunomodulatory molecule in the lung. Whittington, H.A., Armstrong, L., Uppington, K.M., Millar, A.B. Am. J. Respir. Cell Mol. Biol. (2004)
- Crystallization and synchrotron X-ray diffraction studies of human interleukin-22. Nagem, R.A., Lucchesi, K.W., Colau, D., Dumoutier, L., Renauld, J.C., Polikarpov, I. Acta Crystallogr. D Biol. Crystallogr. (2002)