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Gene Review:

Ptpn6 - protein tyrosine phosphatase, non-receptor...

Rattus norvegicus

Synonyms: Protein-tyrosine phosphatase SHP-1, Ptph6, Shp-1, Tyrosine-protein phosphatase non-receptor type 6

Incoronato, M. et al., Choudhry, M.A. et al., Lesourne, R. et al., Marrero, M.B. et al.

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High impact information on Ptpn6

Insufficient phosphorylation prevents fc gamma RIIB from recruiting the SH2 domain-containing protein-tyrosine phosphatase SHP-1 [1].
By using rat pheochromocytoma-derived PC12 cells, here we studied the interactions of Shp-2 and Shp-1 with two activated mutants of Ret receptor, Ret(C634Y) and Ret(M918T) [2].
Ang II inhibits this pathway through the AT(2) receptor activation of the protein tyrosine phosphatase SHP-1 [3].
The decrease in these three protein tyrosine kinases was accompanied by an increase in the activation of the protein tyrosine phosphatase SHP-1 [4].

Biological context of Ptpn6

The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes [2].

References

Insufficient phosphorylation prevents fc gamma RIIB from recruiting the SH2 domain-containing protein-tyrosine phosphatase SHP-1. Lesourne, R., Bruhns, P., Fridman, W.H., Daëron, M. J. Biol. Chem. (2001) [Pubmed]
The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes. Incoronato, M., D'Alessio, A., Paladino, S., Zurzolo, C., Carlomagno, M.S., Cerchia, L., de Franciscis, V. Cell. Signal. (2004) [Pubmed]
The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. Marrero, M.B., Papke, R.L., Bhatti, B.S., Shaw, S., Bencherif, M. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
TGF-beta abrogates TCR-mediated signaling by upregulating tyrosine phosphatases in T cells. Choudhry, M.A., Sir, O., Sayeed, M.M. Shock (2001) [Pubmed]

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