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Gene Review

Ptpn6  -  protein tyrosine phosphatase, non-receptor...

Rattus norvegicus

Synonyms: Protein-tyrosine phosphatase SHP-1, Ptph6, Shp-1, Tyrosine-protein phosphatase non-receptor type 6
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High impact information on Ptpn6


Biological context of Ptpn6


  1. Insufficient phosphorylation prevents fc gamma RIIB from recruiting the SH2 domain-containing protein-tyrosine phosphatase SHP-1. Lesourne, R., Bruhns, P., Fridman, W.H., Daëron, M. J. Biol. Chem. (2001) [Pubmed]
  2. The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes. Incoronato, M., D'Alessio, A., Paladino, S., Zurzolo, C., Carlomagno, M.S., Cerchia, L., de Franciscis, V. Cell. Signal. (2004) [Pubmed]
  3. The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. Marrero, M.B., Papke, R.L., Bhatti, B.S., Shaw, S., Bencherif, M. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  4. TGF-beta abrogates TCR-mediated signaling by upregulating tyrosine phosphatases in T cells. Choudhry, M.A., Sir, O., Sayeed, M.M. Shock (2001) [Pubmed]
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