Gene Review:
Ret - ret proto-oncogene
Rattus norvegicus
Synonyms:
Proto-oncogene tyrosine-protein kinase receptor Ret
- The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants. D'Alessio, A., Califano, D., Incoronato, M., Santelli, G., Florio, T., Schettini, G., Carlomagno, M.S., Cerchia, L., de Franciscis, V. Endocrinology (2003)
- Abrogation of nerve growth factor-induced terminal differentiation by ret oncogene involves perturbation of nuclear translocation of ERK. Colucci-D'Amato, G.L., D'Alessio, A., Califano, D., Cali, G., Rizzo, C., Nitsch, L., Santelli, G., de Franciscis, V. J. Biol. Chem. (2000)
- Signaling through Ras is essential for ret oncogene-induced cell differentiation in PC12 cells. Califano, D., Rizzo, C., D'Alessio, A., Colucci-D'Amato, G.L., Cali, G., Bartoli, P.C., Santelli, G., Vecchio, G., de Franciscis, V. J. Biol. Chem. (2000)
- Expression of Ret receptor tyrosine kinase after transient forebrain ischemia is modulated by glial cell line-derived neurotrophic factor in rat hippocampus. Miyazaki, H., Nagashima, K., Okuma, Y., Nomura, Y. Neurosci. Lett. (2002)
- Glial-cell-line-derived neurotrophic factor induces nerve fibre formation in primary cultures of adrenal chromaffin cells. Förander, P., Broberger, C., Strömberg, I. Cell Tissue Res. (2001)
- NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons. Tsui-Pierchala, B.A., Milbrandt, J., Johnson, E.M. Neuron (2002)
- Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. Creedon, D.J., Tansey, M.G., Baloh, R.H., Osborne, P.A., Lampe, P.A., Fahrner, T.J., Heuckeroth, R.O., Milbrandt, J., Johnson, E.M. Proc. Natl. Acad. Sci. U.S.A. (1997)
- RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase. Knauf, J.A., Kuroda, H., Basu, S., Fagin, J.A. Oncogene (2003)
- The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes. Incoronato, M., D'Alessio, A., Paladino, S., Zurzolo, C., Carlomagno, M.S., Cerchia, L., de Franciscis, V. Cell. Signal. (2004)
- cDNA sequence and genomic structure of the rat RET proto-oncogene. Matera, I., De Miguel-Rodríguez, M., Fernández-Santos, J.M., Santamaria, G., Puliti, A., Ravazzolo, R., Romeo, G., Galera-Davidson, H., Ceccherini, I. DNA Seq. (2000)
- The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. Pelicci, G., Troglio, F., Bodini, A., Melillo, R.M., Pettirossi, V., Coda, L., De Giuseppe, A., Santoro, M., Pelicci, P.G. Mol. Cell. Biol. (2002)
- Upregulation of glial cell line-derived neurotrophic factor and artemin mRNA in the auditory nerve of deafened rats. Wissel, K., Wefstaedt, P., Rieger, H., Miller, J.M., Lenarz, T., Stöver, T. Neuroreport (2006)
- The long and short isoforms of Ret function as independent signaling complexes. Tsui-Pierchala, B.A., Ahrens, R.C., Crowder, R.J., Milbrandt, J., Johnson, E.M. J. Biol. Chem. (2002)
- Expression of GDNF family receptor components during development: implications in the mechanisms of interaction. Yu, T., Scully, S., Yu, Y., Fox, G.M., Jing, S., Zhou, R. J. Neurosci. (1998)
- Inhibition of phosphatidylinositol 3-kinase activity blocks cellular differentiation mediated by glial cell line-derived neurotrophic factor in dopaminergic neurons. Pong, K., Xu, R.Y., Baron, W.F., Louis, J.C., Beck, K.D. J. Neurochem. (1998)
- Effect of neurturin on multipotent cells isolated from the adult skeletal muscle. Vourc'h, P., Lacar, B., Mignon, L., Lucas, P.A., Young, H.E., Chesselet, M.F. Biochem. Biophys. Res. Commun. (2005)
- Heparin facilitates glial cell line-derived neurotrophic factor signal transduction. Tanaka, M., Xiao, H., Kiuchi, K. Neuroreport (2002)
- Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells. Trupp, M., Scott, R., Whittemore, S.R., Ibáñez, C.F. J. Biol. Chem. (1999)
- Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation. Pierchala, B.A., Milbrandt, J., Johnson, E.M. J. Neurosci. (2006)
- Potential role of glial cell line-derived neurotrophic factor receptors in Müller glial cells during light-induced retinal degeneration. Harada, C., Harada, T., Quah, H.M., Maekawa, F., Yoshida, K., Ohno, S., Wada, K., Parada, L.F., Tanaka, K. Neuroscience (2003)
- Responsiveness to neurturin of subpopulations of embryonic rat spinal motoneuron does not correlate with expression of GFR alpha 1 or GFR alpha 2. Garcès, A., Livet, J., Grillet, N., Henderson, C.E., Delapeyrière, O. Dev. Dyn. (2001)
- Differential regulation of GDNF, neurturin, and their receptors in primary cultures of rat glial cells. Rémy, S., Naveilhan, P., Brachet, P., Neveu, I. J. Neurosci. Res. (2001)
- Shared nuclear protein binding sites in the upstream region of the rat opsin gene. Yu, X., Chung, M., Morabito, M.A., Barnstable, C.J. Biochem. Biophys. Res. Commun. (1993)
- Glial cell line-derived neurotrophic factor (GDNF) and its receptor complex are expressed in the auditory nerve of the mature rat cochlea. Stöver, T., Nam, Y., Gong, T.L., Lomax, M.I., Altschuler, R.A. Hear. Res. (2001)