Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Defb6 - defensin beta 6

Mus musculus

Synonyms: BD-6, Beta-defensin 6, Defensin, beta 6, mBD-6

Yamaguchi, Y. et al., Hadjiolov, D. et al., Hamawy, M.M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Defb6

In animal models of endotoxemia, mBD-6 expression was also induced in the lung. mBD-6 showed potent antimicrobial activity against Escherichia coli and would play an important role in host defense in the esophagus, airways, and skeletal muscle. mBD-6 is the first reported beta-defensin predominantly expressed in skeletal muscle [1].

High impact information on Defb6

We demonstrated the expression of mBD-6 in skeletal muscle in addition to the esophagus, tongue, and trachea [1].
A mAb was isolated (mAb BD6) that recognized a surface glycoprotein on rat basophilic leukemia cells (RBL-2H3) [2].
Therefore one of them was selected and different doses of the hydrophilic PDTC were checked for their ability to affect the development of liver and oesophagus tumours induced in BD-6 rats by N-nitrosodiethylamine (NDEA) [3].

Anatomical context of Defb6

A novel mouse beta-defensin, mBD-6, predominantly expressed in skeletal muscle [1].

Analytical, diagnostic and therapeutic context of Defb6

By immunoblotting, mAb BD6 reacted with a 40-kDa protein [2].

References

A novel mouse beta-defensin, mBD-6, predominantly expressed in skeletal muscle. Yamaguchi, Y., Fukuhara, S., Nagase, T., Tomita, T., Hitomi, S., Kimura, S., Kurihara, H., Ouchi, Y. J. Biol. Chem. (2001) [Pubmed]
Inhibition of IgE binding to RBL-2H3 cells by a monoclonal antibody (BD6) to a surface protein other than the high affinity IgE receptor. Hamawy, M.M., Oliver, C., Siraganian, R.P. J. Immunol. (1992) [Pubmed]
Proline dithiocarbamate inhibits N-nitrosodiethylamine induced liver carcinogenesis. Hadjiolov, D., Frank, N., Moog, C., Spirov, K. J. Cancer Res. Clin. Oncol. (1992) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.