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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FAT3  -  FAT atypical cadherin 3

Homo sapiens

Synonyms: CDHF15, CDHR10, Cadherin family member 15, FAT tumor suppressor homolog 3, KIAA1989, ...
 
 
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Disease relevance of FAT3

 

High impact information on FAT3

  • Human and rat fat3 are also similar to the Drosophila tumor suppressor gene fat [1].
  • During this time, robust fat3 immunoreactivity is also observed in the spinal cord [1].
  • Here, complete CDS of human FAT3 and FAT4 were determined by using bioinformatics and human intelligence (Humint) [2].
  • FAT3 gene, consisting of 26 exons, encoded a 4557-aa protein with extracellular 33 Cadherin repeats, one Laminin G (LamG) domain and two EGF domains [2].
  • Cytoplasmic VCSVxPxLP and SDYxS motifs were identified as novel motifs conserved among FAT1, FAT2 and FAT3 orthologs [2].

References

  1. Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs. Mitsui, K., Nakajima, D., Ohara, O., Nakayama, M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Comparative integromics on FAT1, FAT2, FAT3 and FAT4. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2006) [Pubmed]
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