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Gene Review:

CLPS - colipase, pancreatic

Homo sapiens

Synonyms: Colipase

Shea, M.T. et al., Davis, R.C. et al., Lindner, I. et al., Pukrop, R. et al.

Shea, Yen, Pukrop, Krischer,

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Psychiatry related information on CLPS

The present review examines findings from three naturalistic longitudinal studies that utilize similar methodology: the Collaborative Longitudinal Personality Disorders Study (CLPS; Gunderson et al., 2000), the Collaborative Depression Study (CDS; Katz & Klerman, 1979), and the Harvard/Brown Anxiety Research Program (HARP; Keller et al., 1994) [1].

High impact information on CLPS

Southern blot analysis of genomic DNA from a panel of mouse-human somatic cell hybrids indicated that the colipase gene (CLPS) resides on human chromosome 6 [2].
Further analysis of somatic cell hybrids carrying chromosome 6 translocations permitted regional localization of CLPS to the 6p21.1-pter region [2].
The protein encoded by the pancreatic colipase (CLPS) gene is an essential cofactor needed by pancreatic triglyceride lipase (PNLIP) for efficient dietary lipid hydrolysis [3].
Changing views about personality disorders: Comment about the prospective studies CIC, CLPS, and MSAD [4].

References

Stability as a distinction between Axis I and Axis II disorders. Shea, M.T., Yen, S. J. Personal. Disord. (2003) [Pubmed]
Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. Davis, R.C., Xia, Y.R., Mohandas, T., Schotz, M.C., Lusis, A.J. Genomics (1991) [Pubmed]
Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. Lindner, I., Helwig, U., Rubin, D., Li, Y., Fisher, E., Boeing, H., Möhlig, M., Spranger, J., Pfeiffer, A., Hampe, J., Schreiber, S., Döring, F., Schrezenmeir, J. Molecular nutrition & food research. (2005) [Pubmed]
Changing views about personality disorders: Comment about the prospective studies CIC, CLPS, and MSAD. Pukrop, R., Krischer, M. J. Personal. Disord. (2005) [Pubmed]

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