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Gene Review

FGD4  -  FYVE, RhoGEF and PH domain containing 4

Homo sapiens

Synonyms: Actin filament-binding protein frabin, CMT4H, FGD1-related F-actin-binding protein, FRABP, FYVE, RhoGEF and PH domain-containing protein 4, ...
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Disease relevance of FGD4


High impact information on FGD4

  • The cellular expression of either a dominant negative mutant of PI3K (PI3K-Deltap85) or functionally deficient mutants of frabin inhibited C. parvum-induced Cdc42 accumulation at the host cell-parasite interface [2].
  • Frabin having ABD was associated with the actin cytoskeleton, whereas frabin lacking ABD was diffusely distributed in the cytoplasm [3].
  • Full-length frabin induces microspike formation and c-Jun N-terminal kinase (JNK) activation [3].
  • Association of frabin with the actin cytoskeleton is essential for microspike formation through activation of Cdc42 small G protein [3].
  • Frabin furthermore induces indirect activation of Rac small G protein (Rac) in intact cells [4].

Anatomical context of FGD4

  • RESULTS: Frabin induces the formation of microspikes at the basal area of the lateral membranes through the activation of Cdc42 and Rac in MDCK cells, although a dominant active mutant of Cdc42 or Rac alone, or both, did not induce the formation of microspikes [4].

Associations of FGD4 with chemical compounds

  • Frabin also was recruited to the host cell-parasite interface, a process inhibited by two PI3K inhibitors, wortmannin and LY294002 [2].

Other interactions of FGD4


  1. Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4. Stendel, C., Roos, A., Deconinck, T., Pereira, J., Castagner, F., Niemann, A., Kirschner, J., Korinthenberg, R., Ketelsen, U.P., Battaloglu, E., Parman, Y., Nicholson, G., Ouvrier, R., Seeger, J., De Jonghe, P., Weis, J., Krüttgen, A., Rudnik-Schöneborn, S., Bergmann, C., Suter, U., Zerres, K., Timmerman, V., Relvas, J.B., Senderek, J. Am. J. Hum. Genet. (2007) [Pubmed]
  2. Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42. Chen, X.M., Splinter, P.L., Tietz, P.S., Huang, B.Q., Billadeau, D.D., LaRusso, N.F. J. Biol. Chem. (2004) [Pubmed]
  3. Association of frabin with the actin cytoskeleton is essential for microspike formation through activation of Cdc42 small G protein. Umikawa, M., Obaishi, H., Nakanishi, H., Satoh-Horikawa, K., Takahashi, K., Hotta, I., Matsuura, Y., Takai, Y. J. Biol. Chem. (1999) [Pubmed]
  4. Importance of spatial activation of Cdc42 and rac small G proteins by frabin for microspike formation in MDCK cells. Yasuda, T., Ohtsuka, T., Inoue, E., Yokoyama, S., Sakisaka, T., Kodama, A., Takaishi, K., Takai, Y. Genes Cells (2000) [Pubmed]
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