Gene Review:
FGD4 - FYVE, RhoGEF and PH domain containing 4
Homo sapiens
Synonyms:
Actin filament-binding protein frabin, CMT4H, FGD1-related F-actin-binding protein, FRABP, FYVE, RhoGEF and PH domain-containing protein 4, ...
Claudia Stendel,
Andreas Roos,
Tine Deconinck,
Jorge Pereira,
Francois Castagner,
Axel Niemann,
Janbernd Kirschner,
Rudolf Korinthenberg,
Uwe-Peter Ketelsen,
Esra Battaloglu,
Yesim Parman,
Garth Nicholson,
Robert Ouvrier,
Jürgen Seeger,
Peter De Jonghe,
Joachim Weis,
Alexander Krüttgen,
Sabine Rudnik-Schöneborn,
Carsten Bergmann,
Ueli Suter,
Klaus Zerres,
Vincent Timmerman,
João B. Relvas,
Jan Senderek,
- Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4. Stendel, C., Roos, A., Deconinck, T., Pereira, J., Castagner, F., Niemann, A., Kirschner, J., Korinthenberg, R., Ketelsen, U.P., Battaloglu, E., Parman, Y., Nicholson, G., Ouvrier, R., Seeger, J., De Jonghe, P., Weis, J., Krüttgen, A., Rudnik-Schöneborn, S., Bergmann, C., Suter, U., Zerres, K., Timmerman, V., Relvas, J.B., Senderek, J. Am. J. Hum. Genet. (2007)
- Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42. Chen, X.M., Splinter, P.L., Tietz, P.S., Huang, B.Q., Billadeau, D.D., LaRusso, N.F. J. Biol. Chem. (2004)
- Association of frabin with the actin cytoskeleton is essential for microspike formation through activation of Cdc42 small G protein. Umikawa, M., Obaishi, H., Nakanishi, H., Satoh-Horikawa, K., Takahashi, K., Hotta, I., Matsuura, Y., Takai, Y. J. Biol. Chem. (1999)
- Importance of spatial activation of Cdc42 and rac small G proteins by frabin for microspike formation in MDCK cells. Yasuda, T., Ohtsuka, T., Inoue, E., Yokoyama, S., Sakisaka, T., Kodama, A., Takaishi, K., Takai, Y. Genes Cells (2000)