Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

hisM - histidine ABC transporter permease HisM

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Payne, G.M. et al., Stern, M.J. et al.

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Disease relevance of hisM

A mutational hot-spot in the hisM gene of the histidine transport operon in Salmonella typhimurium is due to deletion of repeated sequences and results in an altered specificity of transport [1].

High impact information on hisM

In order to investigate the role of the intercistronic region in intra-operonic control of gene expression, we have isolated MudII-mediated lacZ gene fusions to hisQ, hisM and hisP [2].
While the wild-type transport system does not transport L-histidinol but does transport L-histidine and several of its analogs, the hisM deletion mutants do not transport the latter compounds but do transport L-histidinol [1].

References

A mutational hot-spot in the hisM gene of the histidine transport operon in Salmonella typhimurium is due to deletion of repeated sequences and results in an altered specificity of transport. Payne, G.M., Spudich, E.N., Ames, G.F. Mol. Gen. Genet. (1985) [Pubmed]
Role of the intercistronic region in post-transcriptional control of gene expression in the histidine transport operon of Salmonella typhimurium: involvement of REP sequences. Stern, M.J., Prossnitz, E., Ames, G.F. Mol. Microbiol. (1988) [Pubmed]

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