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Gene Review

dsbA  -  thiol:disulfide interchange protein DsbA

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of dsbA

  • H-NS represses Salmonella enterica serovar Typhimurium dsbA expression during exponential growth [1].
  • The dlp gene was able to complement the DTT-sensitive phenotype, the inability to metabolize glucose 1-phosphate and the low alkaline phosphatase activity of a dsbA mutant of Escherichia coli [2].

High impact information on dsbA


Biological context of dsbA


Analytical, diagnostic and therapeutic context of dsbA

  • Northern blot analysis with a dsbA-specific probe showed an increase in dsbA transcript during exponential phase of growth [1].


  1. H-NS represses Salmonella enterica serovar Typhimurium dsbA expression during exponential growth. Gallant, C.V., Ponnampalam, T., Spencer, H., Hinton, J.C., Martin, N.L. J. Bacteriol. (2004) [Pubmed]
  2. Homologous regions of the Salmonella enteritidis virulence plasmid and the chromosome of Salmonella typhi encode thiol: disulphide oxidoreductases belonging to the DsbA thioredoxin family. Rodríguez-Peña, J.M., Alvarez, I., Ibáñez, M., Rotger, R. Microbiology (Reading, Engl.) (1997) [Pubmed]
  3. RtsA coordinately regulates DsbA and the Salmonella pathogenicity island 1 type III secretion system. Ellermeier, C.D., Slauch, J.M. J. Bacteriol. (2004) [Pubmed]
  4. Isolation and characterization of a chromosomally encoded disulphide oxidoreductase from Salmonella enterica serovar Typhimurium. Turcot, I., Ponnampalam, T.V., Bouwman, C.W., Martin, N.L. Can. J. Microbiol. (2001) [Pubmed]
  5. Cloning and sequencing of the astA gene encoding arylsulfate sulfotransferase from Salmonella typhimurium. Kang, J.W., Kwon, A.R., Kim, D.H., Choi, E.C. Biol. Pharm. Bull. (2001) [Pubmed]
  6. Cloning, sequence analysis, and characterization of the astA gene encoding an arylsulfate sulfotransferase from Citrobacter freundii. Kang, J.W., Jeong, Y.J., Kwon, A.R., Yun, H.J., Kim, D.H., Choi, E.C. Arch. Pharm. Res. (2001) [Pubmed]
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