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Gene Review

trpR  -  Trp operon repressor

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of trpR


High impact information on trpR

  • Strains with LT7-derived trp genes bearing a deletion in trpA produced tryptophan as readily as LT2 trpR prototrophs [1].
  • When feedback inhibition of anthranilate synthetase but not 5'-phosphoribosylpyrophosphate phosphoribosyltransferase activity was by-passed by growing cells on media supplemented with anthranilic acid, all trpR prototrophs overproduced and excreted tryptophan [1].
  • Tn10 insertions near pnuA, pnuC and pnuD were isolated and utilized in mapping studies. pnuA was found to map between thr and serB near trpR [3].


  1. Tryptophan biosynthesis in Salmonella typhimurium: location in trpB of a genetic difference between strains LT2 and LT7. Stuttard, C. J. Bacteriol. (1975) [Pubmed]
  2. The tryptophan repressor sequence is highly conserved among the Enterobacteriaceae. Arvidson, D.N., Arvidson, C.G., Lawson, C.L., Miner, J., Adams, C., Youderian, P. Nucleic Acids Res. (1994) [Pubmed]
  3. Genetic characterization of pyridine nucleotide uptake mutants of Salmonella typhimurium. Spector, M.P., Hill, J.M., Holley, E.A., Foster, J.W. J. Gen. Microbiol. (1985) [Pubmed]
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