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Gene Review:

REL1 - AGAP009515-PA

Anopheles gambiae str. PEST

Synonyms: AgaP_ENSANGG00000008612, ENSANGG00000008612

Cheon, H.M. et al., Bian, G. et al., Frolet, C. et al., Shin, S.W. et al., Shin, S.W. et al.

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Disease relevance of REL1

We have cloned and molecularly characterized the gene homologous to Drosophila Dl and to Anopheles gambiae REL1 (Gambif1) from the yellow fever mosquito Aedes aegypti, named AaREL1 [1].

High impact information on REL1

Here, we showed that these antiparasitic defenses were composed of pre- and postinvasion phases and that the preinvasion phase was predominantly regulated by Rel1 and Rel2 members of the NF-kappaB transcription factors [2].
We took the transgenic approach, in combination with the RNA interference (RNAi) technique, to elucidate the role of mosquito REL1, a homolog of Drosophila Dorsal, in regulation of Toll immune pathway in the mosquito Aedes aegypti [3].
In Vg-DeltaREL1-A transgenic mosquitoes, with gain-of-function phenotype of Toll/REL1 immune pathway activated after blood feeding, both the Lp and LpRfb genes were overexpressed independently of septic injury [4].
This transcriptional up-regulation was mediated by REL1 [5].
These results showed that, in the mosquito fat body, both Lp and LpRfb gene expression were regulated by the Toll/REL1 pathway during immune induction by pathogen and parasite infections [4].

References

REL1, a homologue of Drosophila dorsal, regulates toll antifungal immune pathway in the female mosquito Aedes aegypti. Shin, S.W., Kokoza, V., Bian, G., Cheon, H.M., Kim, Y.J., Raikhel, A.S. J. Biol. Chem. (2005) [Pubmed]
Boosting NF-kappaB-Dependent Basal Immunity of Anopheles gambiae Aborts Development of Plasmodium berghei. Frolet, C., Thoma, M., Blandin, S., Hoffmann, J.A., Levashina, E.A. Immunity (2006) [Pubmed]
Transgenic alteration of Toll immune pathway in the female mosquito Aedes aegypti. Bian, G., Shin, S.W., Cheon, H.M., Kokoza, V., Raikhel, A.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Regulation of lipid metabolism genes, lipid carrier protein lipophorin, and its receptor during immune challenge in the mosquito Aedes aegypti. Cheon, H.M., Shin, S.W., Bian, G., Park, J.H., Raikhel, A.S. J. Biol. Chem. (2006) [Pubmed]
A Toll Receptor and a Cytokine, Toll5A and Spz1C, Are Involved in Toll Antifungal Immune Signaling in the Mosquito Aedes aegypti. Shin, S.W., Bian, G., Raikhel, A.S. J. Biol. Chem. (2006) [Pubmed]

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