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Gene Review

Col7a1  -  collagen, type VII, alpha 1

Mus musculus

Synonyms: AW209154, Collagen alpha-1(VII) chain, LC collagen, Long-chain collagen
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Disease relevance of Col7a1


High impact information on Col7a1


Biological context of Col7a1


Anatomical context of Col7a1

  • Collectively, these findings attest to the complex regulation of Col7a1 transcription in epidermal keratinocytes [2].


  1. Targeted inactivation of the type VII collagen gene (Col7a1) in mice results in severe blistering phenotype: a model for recessive dystrophic epidermolysis bullosa. Heinonen, S., Männikkö, M., Klement, J.F., Whitaker-Menezes, D., Murphy, G.F., Uitto, J. J. Cell. Sci. (1999) [Pubmed]
  2. Transcriptional control of the mouse Col7a1 gene in keratinocytes: basal and transforming growth factor-beta regulated expression. Naso, M., Uitto, J., Klement, J.F. J. Invest. Dermatol. (2003) [Pubmed]
  3. cDNA cloning and chromosomal mapping of the mouse type VII collagen gene (Col7a1): evidence for rapid evolutionary divergence of the gene. Li, K., Christiano, A.M., Copeland, N.G., Gilbert, D.J., Chu, M.L., Jenkins, N.A., Uitto, J. Genomics (1993) [Pubmed]
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