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Gene Review

KCNH8  -  potassium channel, voltage gated eag...

Homo sapiens

Synonyms: ELK, ELK channel 3, ELK1, ELK3, Ether-a-go-go-like potassium channel 3, ...
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High impact information on KCNH8

  • RESULTS: At the doses used in the study, both the PFE and the regular pomegranate juice concentrate reduced the activation of ELK-1 and p-CREB and increased eNOS expression (which was decreased by perturbed shear stress) in cultured human endothelial cells and in atherosclerosis-prone areas of hypercholesterolemic mice [1].
  • KCNH8 was expressed at high levels, and the distribution showed substantial overlap with KCNH3 [2].
  • In Xenopus oocytes, KCNH8 gives rise to slowly activating, voltage-dependent K+ currents that open at hyperpolarized potentials (half-maximal activation at -62 mV) [2].
  • Moreover, these SREs are binding sites for Elk1, suggesting that NO activated Egr-1 gene transcription via activation of Elk1 [3].
  • Likewise, we detected an activation of the transcriptional activation potential of the ternary complex factor Elk1, a key transcriptional regulator of serum response element-driven gene transcription [3].

Biological context of KCNH8

  • In the ets gene family of transcription factors, elk1 belongs to the subfamily of Ternary Complex Factors (TCFs) which bind to the Serum Response Element (SRE) in conjunction with a dimer of Serum Response Factors (SRFs) [4].


  1. Effects of a Pomegranate Fruit Extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis. de Nigris, F., Williams-Ignarro, S., Sica, V., Lerman, L.O., D'Armiento, F.P., Byrns, R.E., Casamassimi, A., Carpentiero, D., Schiano, C., Sumi, D., Fiorito, C., Ignarro, L.J., Napoli, C. Cardiovasc. Res. (2007) [Pubmed]
  2. Distribution and functional properties of human KCNH8 (Elk1) potassium channels. Zou, A., Lin, Z., Humble, M., Creech, C.D., Wagoner, P.K., Krafte, D., Jegla, T.J., Wickenden, A.D. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  3. Nitric oxide-induced programmed cell death in human neuroblastoma cells is accompanied by the synthesis of Egr-1, a zinc finger transcription factor. Cibelli, G., Policastro, V., Rössler, O.G., Thiel, G. J. Neurosci. Res. (2002) [Pubmed]
  4. Structure and organization of the mouse elk1 gene. Grévin, D., Ung, S., Denhez, F., Dehem, M., Quatannens, B., Bègue, A., Stéhelin, D., Martin, P. Gene (1996) [Pubmed]
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