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KCNH3  -  potassium channel, voltage gated eag...

Homo sapiens

Synonyms: BEC1, Brain-specific eag-like channel 1, ELK channel 2, ELK2, Ether-a-go-go-like potassium channel 2, ...
 
 
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Disease relevance of KCNH3

  • Surprisingly, BEC1, formerly thought to be brain-specific, was present in all the primary leukemias examined, in resting peripheral blood lymphocytes, and in proliferating activated tonsillar cells, lymphocytes from Sjögren's patients, and Epstein-Barr virus-transformed B-cells [1].
  • Moreover, we have detected helk2 mRNA and ELK2-like currents in freshly dissociated human astrocytoma cells [2].
 

High impact information on KCNH3

  • We examined transcripts for Kv1.3, h-erg, h-eag, and BEC1 genes in primary lymphocytes and leukemias and in several hematopoietic cell lines [1].
  • The BEC1 gene maps to the 12q13 region of the human genome [3].
  • Transfection of mammalian L929 and Chinese hamster ovary cells with BEC1 cDNA induces a voltage-gated outward current with a fast inactivation component [3].
  • KCNH8 was expressed at high levels, and the distribution showed substantial overlap with KCNH3 [4].
  • Quantitative RT-PCR analysis of mRNA expression patterns showed that KCNH8, along with the other Elk family genes, KCNH3 and KCNH4, are primarily expressed in the human nervous system [4].
 

Biological context of KCNH3

  • Thus, ELK2 channels are active within a wide range of membrane potentials, both sub- and suprathreshold [2].
  • Overall, these properties suggest that ELK2 channels are very effective at dampening the neuronal excitability, but less so at producing adaptation of action potential firing frequency [2].
 

Anatomical context of KCNH3

  • We find that aggregates of both peptides, as well as of A beta(1-42) and A beta(25-35), are toxic to cultured human cerebrovascular endothelial cells (hBEC) obtained from the brain of a victim of AD (at doses lower than those that are toxic to CNS neurons or leptomeningeal smooth muscle cells) [5].
  • Expressional analyses for BEC-1 mRNA with real-time PCR and of BEC-1 protein by Western blotting demonstrated that both were dominantly expressed in the adipose tissues of Sprague-Dawley (SD) rats [6].
 

Other interactions of KCNH3

  • We analyzed and compared the differential expressions of BEC-1 (TUSC5) mRNA and protein in fat tissues between obese homozygous (fa/fa) and lean wild-type (+/+) Zucker rats [6].

References

  1. Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells. Smith, G.A., Tsui, H.W., Newell, E.W., Jiang, X., Zhu, X.P., Tsui, F.W., Schlichter, L.C. J. Biol. Chem. (2002) [Pubmed]
  2. The functional properties of the human ether-à-go-go-like (HELK2) K+ channel. Becchetti, A., De Fusco, M., Crociani, O., Cherubini, A., Restano-Cassulini, R., Lecchi, M., Masi, A., Arcangeli, A., Casari, G., Wanke, E. Eur. J. Neurosci. (2002) [Pubmed]
  3. New ether-à-go-go K(+) channel family members localized in human telencephalon. Miyake, A., Mochizuki, S., Yokoi, H., Kohda, M., Furuichi, K. J. Biol. Chem. (1999) [Pubmed]
  4. Distribution and functional properties of human KCNH8 (Elk1) potassium channels. Zou, A., Lin, Z., Humble, M., Creech, C.D., Wagoner, P.K., Krafte, D., Jegla, T.J., Wickenden, A.D. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  5. Toxicity of various amyloid beta peptide species in cultured human blood-brain barrier endothelial cells: increased toxicity of dutch-type mutant. Eisenhauer, P.B., Johnson, R.J., Wells, J.M., Davies, T.A., Fine, R.E. J. Neurosci. Res. (2000) [Pubmed]
  6. Molecular cloning and characterization of rat brain endothelial cell derived gene-1 (tumor suppressor candidate 5) expressing abundantly in adipose tissues. Shibata, T., Koide, H., Hayashi, R., Nagata, K., Takeo, C., Yoshida, T., Noguchi, Y., Tanaka, T., Saito, Y., Tatsuno, I. Mol. Cell. Endocrinol. (2007) [Pubmed]
 
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