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Gene Review

Defa-rs1  -  defensin, alpha, related sequence 1

Mus musculus

Synonyms: 2010300L12Rik, 2010319H24Rik, Alpha-defensin-related sequence 1, CRS1C, CRS1C-2, ...
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High impact information on Defcr-rs1

  • Unlike cryptdin, however, the proposed CRS1C and CRS4C mature peptide regions lack the structural motif characteristic of defensins [1].
  • Attempts to find homologies between the putative CRS peptides and existing protein sequences have been unsuccessful, leading us to speculate that CRS1C and CRS4C represent a new family of nondefensin antimicrobial peptides in the mouse small bowel [1].
  • Cryptdin and CRS1C mRNAs are not detectable in adult mouse bone marrow, but probes specific for the 5'- or the 3'-untranslated regions of CRS4C mRNA hybridize to a moderately abundant 1.05-kilobase bone marrow mRNA in contrast to a highly abundant 0.75-kilobase mRNA in small intestine [1].
  • The deduced CRS1C and CRS4C polypeptides are apparent precursors of secreted, cationic, proline- and cysteine-rich peptides that contain Cys-Pro-X repeats [1].
  • Thus, both the Defcr-rs1 and the Defcr genes are expressed in Paneth cells and both are genetically inseparable within 1.58 cM on Chromosome 8 [2].

Biological context of Defcr-rs1


Analytical, diagnostic and therapeutic context of Defcr-rs1


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