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Gene Review

Diap1  -  diaphanous homolog 1 (Drosophila)

Mus musculus

Synonyms: D18Wsu154e, DRF1, Dia1, Diaph1, Diaphanous-related formin-1, ...
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Disease relevance of Diap1


High impact information on Diap1


Biological context of Diap1


Other interactions of Diap1

  • In inner-ear-derived cell lines, expression of mutated Rac1 changed the structural arrangement of F-actin and diminished the immunoreactivity of p140mDia [7].
  • We have identified a protein, p140mDia, as a downstream effector of Rho [8].


  1. T cell responses in mammalian diaphanous-related formin mDia1 knock-out mice. Eisenmann, K.M., West, R.A., Hildebrand, D., Kitchen, S.M., Peng, J., Sigler, R., Zhang, J., Siminovitch, K.A., Alberts, A.S. J. Biol. Chem. (2007) [Pubmed]
  2. Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling. Tominaga, T., Sahai, E., Chardin, P., McCormick, F., Courtneidge, S.A., Alberts, A.S. Mol. Cell (2000) [Pubmed]
  3. The Rho family GTPase Rif induces filopodia through mDia2. Pellegrin, S., Mellor, H. Curr. Biol. (2005) [Pubmed]
  4. Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42. Peng, J., Wallar, B.J., Flanders, A., Swiatek, P.J., Alberts, A.S. Curr. Biol. (2003) [Pubmed]
  5. The diaphanous-related formin mDia1 controls serum response factor activity through its effects on actin polymerization. Copeland, J.W., Treisman, R. Mol. Biol. Cell (2002) [Pubmed]
  6. Identification of a carboxyl-terminal diaphanous-related formin homology protein autoregulatory domain. Alberts, A.S. J. Biol. Chem. (2001) [Pubmed]
  7. Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics. Jiang, H., Sha, S.H., Schacht, J. J. Neurosci. Res. (2006) [Pubmed]
  8. p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. Watanabe, N., Madaule, P., Reid, T., Ishizaki, T., Watanabe, G., Kakizuka, A., Saito, Y., Nakao, K., Jockusch, B.M., Narumiya, S. EMBO J. (1997) [Pubmed]
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