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Gene Review

dia  -  diaphanous

Drosophila melanogaster

Synonyms: 38E.16, CG1768, DIA, Dia, Dias, ...
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Disease relevance of dia


High impact information on dia


Biological context of dia

  • Immunolocalization studies of wild-type embryos reveal that Diaphanous localizes to the site where the metaphase furrow is anticipated to form, to the growing tip of cellularization furrows, and to contractile rings [6].
  • Based on known biochemical functions of FH proteins, we propose that Diaphanous serves as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle [6].
  • Male-sterile alleles of chickadee and diaphanous, which are deficient in germ cells, exhibit similar cyst cell phenotypes [7].
  • Conversely, depletion of endogenous diaphanous protein in BG2-C2 cells by RNA interference (RNAi) stimulates the mitochondrial movement [8].
  • Several lines of evidence indicate that mDia1 and diaphanous are essential in cytokinesis. mDia1 is present in a large amount in the cytoplasm of both interphase and mitotic cells [9].

Anatomical context of dia

  • Our findings thus indicate that Diaphanous has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination [6].
  • Co-expression of dominant negative Rho-kinase and constitutive active Rho1 also induces filopodia formation, with Diaphanous enriched at the tips [10].
  • Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells [9].
  • The observed effects are highly specific to mitochondria since perturbations of diaphanous or mDia1 have no effect on movement of other membrane organelles [8].
  • The ROK inhibition-resistant stress fibers and FAs were lost upon the overexpression of the dominant-negative form of mDia1 (a mammalian homolog of Drosophila diaphanous protein) [11].

Other interactions of dia

  • PATIENTS: One affected child and 2 affected adults of the Costa Rican kindred who harbor a mutation in the diaphanous gene [3].


  1. RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation. Grosshans, J., Wenzl, C., Herz, H.M., Bartoszewski, S., Schnorrer, F., Vogt, N., Schwarz, H., Müller, H.A. Development (2005) [Pubmed]
  2. A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility. Bione, S., Sala, C., Manzini, C., Arrigo, G., Zuffardi, O., Banfi, S., Borsani, G., Jonveaux, P., Philippe, C., Zuccotti, M., Ballabio, A., Toniolo, D. Am. J. Hum. Genet. (1998) [Pubmed]
  3. Further characterization of the DFNA1 audiovestibular phenotype. Lalwani, A.K., Jackler, R.K., Sweetow, R.W., Lynch, E.D., Raventós, H., Morrow, J., King, M.C., León, P.E. Arch. Otolaryngol. Head Neck Surg. (1998) [Pubmed]
  4. Cooperative interactions between the central spindle and the contractile ring during Drosophila cytokinesis. Giansanti, M.G., Bonaccorsi, S., Williams, B., Williams, E.V., Santolamazza, C., Goldberg, M.L., Gatti, M. Genes Dev. (1998) [Pubmed]
  5. Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Dean, S.O., Rogers, S.L., Stuurman, N., Vale, R.D., Spudich, J.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Functional analysis of the Drosophila diaphanous FH protein in early embryonic development. Afshar, K., Stuart, B., Wasserman, S.A. Development (2000) [Pubmed]
  7. The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis. Gönczy, P., DiNardo, S. Development (1996) [Pubmed]
  8. Regulation of mitochondria distribution by RhoA and formins. Minin, A.A., Kulik, A.V., Gyoeva, F.K., Li, Y., Goshima, G., Gelfand, V.I. J. Cell. Sci. (2006) [Pubmed]
  9. Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells. Kato, T., Watanabe, N., Morishima, Y., Fujita, A., Ishizaki, T., Narumiya, S. J. Cell. Sci. (2001) [Pubmed]
  10. Reciprocal regulation of Rac1 and Rho1 in Drosophila circulating immune surveillance cells. Williams, M.J., Habayeb, M.S., Hultmark, D. J. Cell. Sci. (2007) [Pubmed]
  11. Rho-mediated assembly of stress fibers is differentially regulated in corneal fibroblasts and myofibroblasts. Anderson, S., DiCesare, L., Tan, I., Leung, T., SundarRaj, N. Exp. Cell Res. (2004) [Pubmed]
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