Disease relevance of Dnase2a

• Podophyllin induced intense uniform I.F.E. hyperplasia without any proliferation of poorly differentiated basal cells, without increased nucleic acid staining and without any appreciably decreased acid DNAse activity [1].

High impact information on Dnase2a

• In one, the DNA fragmentation is carried out by CAD in the dying cells and in the other, by lysosomal DNase II after the dying cells are phagocytosed [2].
• In the present study, we undertook kinetic analyses of DNA degradation and acid DNase activity in murine thymus after administration of hydrocortisone [3].
• The distribution of acid DNase-active cells appeared to be similar to that of F4/80+ macrophages [3].
• These data provide direct evidence implicating lysosomal DNase II as a barrier to transfection [4].
• In jpmsd mice, however, the DNA content as well as the incorporation of thymidine in DNA were reduced in both cerebellum and cerebrum, but the activity of acid DNase was reduced in cerebrum only [5].

Anatomical context of Dnase2a

• The DNA content, the in vivo incorporation of [14C]thymidine in DNA and the activity of acid DNase in tissues (cerebellum and cerebrum) from normal littermates and affected mice were compared [5].
• The results obtained suggest that rise in acid DNase activity takes place during the process of lymphocyte activation by mitogens [6].

References