Disease relevance of Dnase2

• The specific activity of acid DNase was unaffected by weaning undernutrition in both white and grey matter [1].

Psychiatry related information on Dnase2

• Effect of alcohol consumption on the activity of two lysosomal nucleases, deoxyribonuclease II (DNAase II) and ribonuclease II (RNAase II) and calcium concentration have been studied during liver regeneration of Sprague-Dawley rats over a period of 10 days following 70% partial hepatectomy [2].

High impact information on Dnase2

• Studies on lysosomal enzymes showed that purified K cells possess higher specific activities in beta-glucuronidase, acid DNase, and cathepsin D than in purified parenchymal cells [3].
• The influence of aging on lysosomal acid DNase of the rat submandibular gland [4].
• Radiation effects on rat testes. V. Studies on lysosomal enzymes (acid phosphatase and acid DNAse) and their physiological significance following partial body gamma-irradiation [5].
• An initial increase in acid phosphatase is matched by an initial rise in acid DNAse within hours of irradiation, further suggesting that there is radiation interaction with the cells of the germinal epithelium [5].
• The activity of acid DNase was reduced in both cerebellum and cerebrum from 11 as well as 21 day old rats treated with PCPA plus PHE, but the enzyme activity was not altered in the tissues from rats of both ages treated with alpha MPA plus PHE [6].

Biological context of Dnase2

• The acid DNase displays typical Michaelis-Menten kinetics but the kinetics became sigmoidal in the presence of the inhibitor [7].

Anatomical context of Dnase2

• Bovine serum albumin was found to have an inhibitory effect on acid DNase from rat small intestinal mucosa [7].
• Release of ribonucleoprotein during digestion of rat testis chromatin with deoxyribonuclease II (3.1.4.6) [8].
• They are digested with deoxyribonuclease II and four subfractions are isolated after differential centrifugation: MgCl2-soluble (active) and MgCl2-insoluble (inactive) chromatin, nuclear matrix sediment and matrix extract using 2M NaCl [9].

Associations of Dnase2 with chemical compounds

• The effect of methylnitrosourea (MNU) on cerebellar and cerebral DNA, RNA, protein, lysosomal enzymes (acid DNase, RNase, phosphatase, and beta-glucuronidase), and 2',3'-cyclic nucleotide 3'-phosphohydrolase (2',3'-CNPase) activities was studied in rats from birth through 12 days of age [10].

References