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Gene Review

CPN2  -  carboxypeptidase N, polypeptide 2

Homo sapiens

Synonyms: ACBP, Carboxypeptidase N 83 kDa chain, Carboxypeptidase N large subunit, Carboxypeptidase N polypeptide 2, Carboxypeptidase N regulatory subunit, ...
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Disease relevance of CPN2

  • 2. There is a CPN2 soma and neuropilar arborization in each commissural ganglion (CoG) [1].

High impact information on CPN2

  • In tetrameric CPN, each CPN1 subunit might interact with the central leucine-rich repeat tandem of the cognate CPN2 subunit via a unique hydrophobic surface patch wrapping around the catalytic domain-TT interface, exposing the two active centers [2].
  • CPN2 also indirectly inhibits gastric mill neurons Int1 and VD (interneuron 1 and ventricular dilator neuron, respectively) through its activation of LG [1].
  • The CPN2 excitatory effects are mediated at least partly via discrete excitatory postsynaptic potentials (EPSPs; Fig. 4B), whereas its inhibitory effects are produced via smooth hyperpolarizations [1].
  • We also demonstrate that MPN has no proctolin-mediated influence on MCN1 or CPN2, although exogenously applied proctolin directly excites these neurons [3].

Chemical compound and disease context of CPN2

  • Here, we show that MPN uses only its small molecule transmitter, GABA, to inhibit MCN1 and CPN2 within their ganglion of origin [3].

Anatomical context of CPN2

  • Normally, CPN circulates in blood plasma as a hetero-tetramer consisting of two 83 kDa (CPN2) domains each flanked by a 48 to 55 kDa catalytic (CPN1) domain [2].


  1. Recruitment of a projection neuron determines gastric mill motor pattern selection in the stomatogastric nervous system of the crab, Cancer borealis. Norris, B.J., Coleman, M.J., Nusbaum, M.P. J. Neurophysiol. (1994) [Pubmed]
  2. Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain. Keil, C., Maskos, K., Than, M., Hoopes, J.T., Huber, R., Tan, F., Deddish, P.A., Erdös, E.G., Skidgel, R.A., Bode, W. J. Mol. Biol. (2007) [Pubmed]
  3. Distinct functions for cotransmitters mediating motor pattern selection. Blitz, D.M., Nusbaum, M.P. J. Neurosci. (1999) [Pubmed]
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