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Gene Review

Fzd4  -  frizzled homolog 4 (Drosophila)

Mus musculus

Synonyms: Frizzled-4, Fz-4, Fz4, mFz4
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High impact information on Fzd4

  • Norrin and Frizzled4 (Fz4) function as a ligand-receptor pair to control vascular development in the retina and inner ear [1].
  • Although a recently identified, high-affinity FZD4 ligand Norrin (Norrie disease pseudoglioma homolog) is expressed in the ovary, adult Ndph-/- mice contain functional corpora lutea and do not phenocopy Fzd4-/- mice [2].
  • Thus, Fzd4 appears to impact the formation of the corpus luteum by mechanisms that more closely phenocopy Prlr null mice [2].
  • Histological and functional analyses of ovaries from timed mating pairs at Days 1.5-7.5 postcoitus (p.c.) indicate that the corpora lutea of the Fzd4-/- mice do not develop normally [2].
  • Using deletion mapping, we localized the Frizzled4 (Fzd4) gene to the jdf/thymus and cardiac development intervals [3].

Biological context of Fzd4

  • In contrast to the early cell proliferation and patterning effects classically ascribed to Wnts, the auditory and cerebellar phenotypes of fz4(-/-) mice implicate Frizzled signaling in maintaining the viability and integrity of the nervous system in later life [4].

Anatomical context of Fzd4


  1. Mutational analysis of norrin-frizzled4 recognition. Smallwood, P.M., Williams, J., Xu, Q., Leahy, D.J., Nathans, J. J. Biol. Chem. (2007) [Pubmed]
  2. Mice null for Frizzled4 (Fzd4-/-) are infertile and exhibit impaired corpora lutea formation and function. Hsieh, M., Boerboom, D., Shimada, M., Lo, Y., Parlow, A.F., Luhmann, U.F., Berger, W., Richards, J.S. Biol. Reprod. (2005) [Pubmed]
  3. Mouse fzd4 maps within a region of chromosome 7 important for thymus and cardiac development. DeRossi, C., Laiosa, M.D., Silverstone, A.E., Holdener, B.C. Genesis (2000) [Pubmed]
  4. Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene. Wang, Y., Huso, D., Cahill, H., Ryugo, D., Nathans, J. J. Neurosci. (2001) [Pubmed]
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