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Gene Review

Ta1490  -  tricorn protease

Thermoplasma acidophilum DSM 1728

 
 
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Disease relevance of Ta1490

 

High impact information on Ta1490

  • The cap domain mainly confers the specificity for hydrophobic side chains by a novel cavity system, which, analogously to the tricorn protease, guides substrates to the buried active site and products away from it [3].
  • The proposed pathway and mechanism of substrate entry and product egress in the hexameric D3 symmetric tricorn protease from Thermoplasma acidophilum were explored by crystallographic studies of ligand complexes and by structure-based mutagenesis [4].
  • Hitherto, the occurrence of Tricorn protease seemed to be limited to some archaea, but genes encoding Tricorn homologs have now been found in several bacterial genomes [2].
 

Analytical, diagnostic and therapeutic context of Ta1490

References

  1. Crystal structure of the tricorn protease reveals a protein disassembly line. Brandstetter, H., Kim, J.S., Groll, M., Huber, R. Nature (2001) [Pubmed]
  2. Tricorn protease in bacteria: characterization of the enzyme from Streptomyces coelicolor. Tamura, N., Pfeifer, G., Baumeister, W., Tamura, T. Biol. Chem. (2001) [Pubmed]
  3. Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism. Goettig, P., Groll, M., Kim, J.S., Huber, R., Brandstetter, H. EMBO J. (2002) [Pubmed]
  4. Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum. Kim, J.S., Groll, M., Musiol, H.J., Behrendt, R., Kaiser, M., Moroder, L., Huber, R., Brandstetter, H. J. Mol. Biol. (2002) [Pubmed]
  5. Capsids of tricorn protease studied by electron cryomicroscopy. Walz, J., Koster, A.J., Tamura, T., Baumeister, W. J. Struct. Biol. (1999) [Pubmed]
  6. Purification, crystallization, and preliminary X-ray diffraction analysis of the Tricorn protease hexamer from Thermoplasma acidophilum. Bosch, J., Tamura, T., Bourenkov, G., Baumeister, W., Essen, L.O. J. Struct. Biol. (2001) [Pubmed]
 
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